Fig. 3

Influence of apoC1 on lipoprotein metabolism. ApoC1 acts on the metabolism of triglyceride-rich lipoproteins, leading to an increase in plasma TG levels by promoting TRL secretion by and inhibiting TG hydrolysis as well as TRL remnant clearance. ApoC1 also acts on the metabolism of HDL by favouring HDL maturation and by limiting the net loss of cholesteryl esters toward VLDL and LDL. (1) ApoC1 inhibits LPL activity. (2) ApoC1 inhibits the binding of triglyceride-rich lipoproteins to LDL-R. (3) ApoC1 inhibits the binding of triglyceride-rich lipoproteins to LRP. (4) ApoC1 inhibits the binding of triglyceride-rich lipoproteins to VLDL-R. (5) ApoC1 stimulates the hepatic production of VLDL. (6) ApoC1 is the physiological inhibitor of CETP. (7) ApoC1 stimulates LCAT activity. (8) ApoC1 inhibits SR-BI. ABCA1 ATP-binding cassette A1, ABCG1 ATP-binding cassette G1, CETP cholesteryl ester transfer protein, HDL high density lipoprotein, HL hepatic lipase, IDL intermediate density lipoprotein, LCAT lecithin-cholesterol acyltransferase, LDL low density lipoprotein, LDL-R LDL receptor, LPL lipoprotein lipase, LRP LDLR related protein, PLTP phospholipid transfer protein, VLDL very low density lipoprotein, VLDL-R VLDL receptor