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Table 3 Association of rs233109 with diabetic macroangiopathy grouped by Hp genotype

From: The effect of haptoglobin genotype on the association of asymmetric dimethylarginine and DDAH 1 polymorphism with diabetic macroangiopathy

 

Hp 1 Carriers

 

Hp 2–2

 

OR (95% CI)

P value

 

OR (95% CI)

P value

Crude

     

CC

0.943 (0.653, 1.363)

0.756

 

1.570 (1.090, 2.261)

0.015

TC

0.935 (0.718, 1.216)

0.614

 

1.228 (0.963, 1.565)

0.098

TT

1 (Reference)

  

1 (Reference)

 

P for interaction

0.037

Model 1

     

CC

0.846 (0.531, 1.348)

0.481

 

1.626 (1.038, 2.547)

0.034

TC

0.917 (0.660, 1.276)

0.609

 

1.370 (1.012, 1.856)

0.042

TT

1 (Reference)

  

1 (Reference)

 

P for interaction

0.021

Model 2

     

CC

0.846 (0.527, 1.359)

0.490

 

1.750 (1.101, 2.783)

0.018

TC

0.944 (0.673, 1.323)

0.737

 

1.386 (1.015, 1.892)

0.040

TT

1 (Reference)

  

1 (Reference)

 

P for interaction

0.017

  1. DDAH1 rs233109 genotypes: CC, TC, and TT. Model 1 was adjusted for age, sex, BMI, duration of diabetes, and HbA1c. Model 2 included variables in model 1 plus blood pressure, TC, and LDL-C
  2. Hp haptoglobin; Hp 1 carriers Hp 1-1 and Hp 2-1