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Table 1 Baseline characteristics of the study cohort

From: Unsupervised machine learning based on clinical factors for the detection of coronary artery atherosclerosis in type 2 diabetes mellitus

 

Cluster 1 (n = 463)

Cluster 2 (n = 341)

Cluster 3 (n = 353)

P value

Male (%)

193(41.7%)

226(66.3%)a

341(96.6%)a,b

 < 0.001

Age (years old)

71.44 ± 9.21

69.98 ± 9.56

65.89 ± 10.15a,b

 < 0.001

BMI (kg/m2)

24.69 ± 3.51

24.71 ± 3.38

24.64 ± 3.26

0.856

Smoking history (%)

0(0.0%)

130(38.1%)a

322(91.2%)a,b

 < 0.001

Alcohol (%)

4(0.9%)

96(28.2%)a

211 (59.8%)a,b

 < 0.001

Hypertension (%)

389(84.0%)

254(74.5%)a

280(79.3%)

0.004

Systolic blood pressure (mmHg)

137.71 ± 19.45

136.04 ± 20.27

136.48 ± 20.69

0.297

Diastolic blood pressure (mmHg)

79.82 ± 12.61

77.60 ± 11.51

81.31 ± 13.30b

0.001

Pulse pressure (mmHg)

57.89 ± 17.13

58.43 ± 17.66

55.16 ± 15.33b

0.028

CAD family history (%)

19(4.1%)

14(4.1%)

30(8.5%)a

0.010

Diabetes duration (year)

9.94 ± 7.29

7.90 ± 8.20a

9.70 ± 7.37b

 < 0.001

HbA1c (%)

7.41 ± 1.48

7.52 ± 1.65

7.62 ± 1.54

0.158

Fasting blood glucose (mmol/L)

7.50 ± 2.60

7.99 ± 2.91

7.56 ± 2.58

0.064

Cholesterol(mmol/L)

3.96 ± 1.18

4.06 ± 1.12

3.89 ± 1.06

0.175

Triglyceride(mmol/L)

1.58 ± 1.08

1.64 ± 1.28

1.65 ± 1.02

0.124

HDL-C(mmol/L)

1.16 ± 0.31

1.12 ± 0.35

1.07 ± 0.28a,b

 < 0.001

LDL-C(mmol/L)

2.22 ± 0.93

2.32 ± 0.92

2.23 ± 0.87

0.298

Serum uric acid (µmol/L)

318.97 ± 97.29

328.26 ± 98.99

337.27 ± 90.12a

0.014

eGFR(ml/min/1.73m2)

78.75 ± 17.08

78.72 ± 16.95

83.81 ± 19.06a,b

 < 0.001

Serum creatinine (µmol/L)

74.46 ± 22.18

79.79 ± 21.97a

81.77 ± 23.20a

 < 0.001

Diabetes treatment (%)

 Oral

463(100.0%)

0(0.0%)a

353(100.0%)b

 < 0.001

 Biguanides

257(55.5%)

0(0.0%)a

217(61.5%)b

 < 0.001

 α-Glucosidase inhibitor

153(33.0%)

0(0.0%)a

137(38.8%)b

 < 0.001

 Sulfonylureas

123(26.6%)

0(0.0%)a

84(23.8%)b

 < 0.001

 Insulin

119(25.7%)

122(35.8%)a

101(28.6%)

0.007

 Without drug

0(0.0%)

197(57.8%)a

0(0.0%)b

 < 0.001

 Statins (%)

123(26.6%)

60(17.6%)a

97(27.5%)b

0.003

  1. aIndicates that the difference between cluster group 2 or cluster group 3 and cluster group 1 is statistically significant
  2. bIndicates that the difference between cluster group 3 and cluster group 2 is statistically significan t