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Table 2 Rate ratios (RR) of diabetes-related complications according to lipid lowering drug use (A) and antihypertensive drug use (B)

From: Time trends of cardiovascular risk management in type 1 diabetes - nationwide analyses of real-life data

 

Continued vs. Never

Continued vs. Discontinued

Discontinued vs. Never

RR

95% CI

RR

95% CI

RR

95% CI

Cardiovascular disease

0.85

(0.73–0.98)

0.59

(0.49–0.71)

1.45

(1.21–1.73)

Cerebrovascular disease

0.91

(0.74–1.12)

0.58

(0.45–0.76)

1.56

(1.21–2.03)

Ischeamic heart disease

1.17

(0.96–1.42)

0.72

(0.56–0.92)

1.63

(1.27–2.1)

Heart failure

1.03

(0.8–1.33)

0.7

(0.51–0.98)

1.47

(1.04–2.07)

Atherosclerotic macrovascular disease

1.03

(0.8–1.34)

0.69

(0.49–0.95)

1.51

(1.08–2.12)

Atrial fibrillation

0.87

(0.67–1.13)

0.62

(0.44–0.86)

1.41

(1.01–1.99)

Chronic Kidney disease

0.9

(0.7–1.14)

0.7

(0.51–0.95)

1.29

(0.93–1.78)

Severe chronic kidney disease

1.22

(0.52–2.9)

0.72

(0.29–1.79)

1.69

(0.62–4.6)

End-stage chronic kidney disease

0.82

(0.58–1.15)

0.49

(0.33–0.73)

1.66

(1.11–2.48)

Microalbuminuria

1.04

(0.9–1.2)

0.76

(0.64–0.91)

1.36

(1.14–1.62)

Macroalbuminuria

0.97

(0.71–1.3)

0.74

(0.51–1.06)

1.31

(0.91–1.89)

Minor amputation

0.71

(0.46–1.09)

0.68

(0.39–1.2)

1.04

(0.59–1.83)

Major amputation

1.01

(0.65–1.57)

0.51

(0.31–0.85)

1.97

(1.16–3.35)

Moderate-severe retinopathy

1.01

(0.83–1.24)

0.81

(0.63–1.05)

1.25

(0.97–1.6)

 

Continued vs. Never

Continued vs. Discontinued

Discontinued vs. Never

RR

95% CI

RR

95% CI

RR

95% CI

Cardiovascular Disease

3.08

(2.46–3.86)

0.98

(0.75–1.27)

3.15

(2.43–4.09)

Cerebrovascular disease

2.63

(1.89–3.67)

0.72

(0.5–1.03)

3.67

(2.54–5.29)

Ischeamic heart disease

2.67

(1.94–3.69)

1.3

(0.9–1.86)

2.06

(1.4–3.05)

Heart failure

8.69

(5.47–13.81)

1.16

(0.76–1.77)

7.46

(4.39–12.69)

Atherosclerotic macrovascular disease

2.88

(1.85–4.48)

1.48

(0.9–2.43)

1.94

(1.1–3.43)

Atrial fibrillation

2.89

(1.88–4.42)

1.42

(0.84–2.38)

2.03

(1.14–3.62)

Chronic Kidney disease

15.08

(9.6–23.67)

3.78

(2.23–6.4)

3.99

(2.15–7.4)

Severe chronic kidney disease

129.12

(13.99–1191.92)

4.21

(1.07–16.55)

30.68

(2.73–344.77)

End-stage chronic kidney disease

23.5

(13.63–40.5)

3.83

(2.08–7.08)

6.13

(2.97–12.66)

Microalbuminuria

1.88

(1.4–2.54)

1.08

(0.81–1.45)

1.74

(1.28–2.38)

Macroalbuminuria

13.48

(7.05–25.8)

1.74

(1.01–3.01)

7.74

(3.86–15.51)

Minor amputation

3.36

(1.56–7.24)

1.97

(0.86–4.47)

1.71

(0.66–4.41)

Major amputation

3.42

(1.74–6.75)

2.88

(1.16–7.13)

1.19

(0.43–3.28)

Moderate-severe retinopathy

1.06

(0.69–1.63)

0.62

(0.4–0.95)

1.7

(1.13–2.57)

  1. Never use: the period before the first use of LLD; Continued use: the period(s) a person is using LLD; discontinued use: period(s) where the person is not using LLD, but previously has