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Table 1 Characteristics of participants at EDIC baseline by tertiles of ASV distribution

From: Body-weight variability and risk of cardiovascular outcomes in patients with type 1 diabetes: a retrospective observational analysis of data from the DCCT/EDIC population

 

All

ASV Tertiles

P

 

T1

T2

T3

N

1,398

465

468

465

 

ASV, kg*

2.33 [1.69]

1.43 [0.52]

2.33 [0.48]

3.90 [1.58]

 < 0.0001

DCCT group: intensive treatment, n (%)

693 (50)

187 (40)

225 (48)

281 (60)

 < 0.0001

Duration of DCCT follow-up, years

6.2 ± 1.8

6.0 ± 1.7

6.4 ± 1.8

6.1 ± 1.8

0.0002

Duration of EDIC follow-up, years

20.0 ± 3.3

20.1 ± 3.0

20.0 ± 3.3

19.9 ± 3.5

0.50

Sex: male, n (%)

733 (52)

260 (56)

265 (57)

208 (45)

0.0002

Age, years

33 ± 7

34 ± 7

34 ± 7

32 ± 7

 < 0.0001

BMI, kg/m2

25.8 ± 3.8

24.2 ± 2.7

25.8 ± 3.2

27.4 ± 4.7

 < 0.0001

Duration of diabetes, years

12 ± 5

12 ± 5

13 ± 5

12 ± 5

0.0005

HbA1c, %

8.3 ± 1.6

8.3 ± 1.6

8.3 ± 1.6

8.2 ± 1.7

0.24

HbA1c, mmol/mol

67 ± 18

68 ± 17

67 ± 17

66 ± 19

0.24

Systolic BP, mmHg

117 ± 12

117 ± 12

117 ± 12

116 ± 11

0.28

Diastolic BP, mmHg

75 ± 9

74 ± 9

75 ± 9

74 ± 9

0.25

Arterial hypertension, n (%)

57 (4.1)

11 (2.4)

26 (5.6)

20 (4.3)

0.05

Total cholesterol, mmol/L

4.72 ± 0.89

4.65 ± 0.85

4.68 ± 0.80

4.82 ± 0.96

0.007

LDL-cholesterol, mmol/L

2.94 ± 0.77

2.88 ± 0.74

2.92 ± 0.76

3.02 ± 0.80

0.02

HDL-cholesterol, mmol/L

1.33 ± 0.34

1.35 ± 0.35

1.32 ± 0.34

1.32 ± 0.32

0.20

Triglycerides, mmol/L*

0.83 [0.49]

0.75 [0.48]

0.83 [0.52]

0.88 [0.53]

 < 0.0001

Hyperlipidemia, n (%)

387 (28)

106 (23)

139 (30)

142 (31)

0.01

eGFR, ml/min/1.73m2

117 ± 13

116 ± 12

116 ± 12

119 ± 14

0.008

UAE, mg/24 h*

10 [12]

9 [9]

10 [13]

9 [13]

0.02

UAE > 30 mg/24 h, n (%)

149 (11)

41 (9)

66 (14)

42 (9)

0.01

Tobacco smoking, n (%)

278 (20)

83 (18)

88 (19)

107 (23)

0.10

Family history of MI, n (%)

681 (49)

220 (47)

230 (49)

231 (50)

0.74

Family history of T2D, n (%)

126 (9)

38 (8)

41 (9)

47 (10)

0.57

  1. Data from EDIC baseline, unless stated otherwise. Continuous data expressed as mean ± SD or as median [IQR]*. Categorical data expressed as number (%). Statistics are ANOVA, *Kruskal–Wallis test or Pearson's chi-squared test. ASV: Average Successive Variability index of body-weight variability during DCCT follow-up. Arterial hypertension: Systolic BP > 140 mmHg or Diastolic BP > 90 mmHG or use of antihypertensive drug. Hyperlipidemia: LDL-cholesterol 3.37 ≥ mmol/L (130 mg/dl) or use of lipid-lowering drug. eGFR estimated glomerular filtration rate. UAE Urinary albumin excretion. MI myocardial infarction. T2D type 2 diabetes