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Table 2 Postoperative outcomes according to preoperative DM

From: Impact of diabetes mellitus on long-term clinical and graft outcomes after off-pump coronary artery bypass grafting with pure bilateral skeletonized internal thoracic artery grafts

 

Non-DM group

DM group

Unadjusted

Multivariable adjusted*

Propensity-score matched

HR

95% CI

P-value

HR

95% CI

P-value

HR

95% CI

P-value

Early clinical outcomes (< 30 days)

N = 1884

N = 1511

      

N = 2786 (1393 Pairs)

 Early mortality

7 (0.5%)

4 (0.3%)

0.716

0.209–2.450

0.764

   

0.570

0.167–1.952

0.504

 Bleeding requiring reoperation

19 (1.0%)

18 (1.2%)

1.183

0.619–2.263

0.731

   

2.266

0.982–5.230

0.076

 Graft related reoperation

7 (0.4%)

6 (0.4%)

1.069

0.359–3.188

 > 0.999

   

1.000

0.322–3.108

> 0.999

 Myocardial infarction

2 (0.1%)

0 (0.0%)

NA

NA

NA

   

NA

NA

NA

 Stroke

10 (0.5%)

12 (0.8%)

1.500

0.646–3.482

0.462

   

1.336

0.561.3.181

0.661

 Atrial fibrillation

51 (2.7%)

50 (3.3%)

1.230

0.828–1.828

0.355

   

1.025

0.662–1.587

> 0.999

 Acute kidney injury

63 (3.8%)

116 (8.6%)

2.354

1.717–3.228

< 0.001

   

1.877

1.322–2.666

0.001

 Dialysis

3 (0.2%)

16 (1.6%)

6.811

1.979–23.443

0.001

   

3.744

1.041–13.466

0.057

 Wound infection

32 (1.7%)

86 (5.7%)

3.493

2.314–5.272

< 0.001

   

3.202

2.026–5.059

< 0.001

Repeated wound infection

7 (0.4%)

15 (1.0%)

2.689

1.093–6.611

0.043

   

2.178

0.825–5.746

0.167

Clinical outcomes at 10 year

           

 Cardiac death

30 (3.3%)

30 (5.1%)

1.407

0.848–2.358

0.186

0.885

0.451–1.734

0.722

0.954

0.544–1.669

0.865

 Myocardial infarction

27 (4.6%)

19 (5.0%)

1.060

0.581–1.931

0.846

0.815

0.845–1.077

0.594

0.998

0.528–1.921

0.996

 Repeat revascularization

65 (9.6%)

47 (12.8%)

1.079

0.733–1.587

0.692

1.241

0.838–1.838

0.281

1.137

0.742–1.741

0.545

 MACE

77 (17.1%)

99 (13.6%)

1.141

0.846–1.546

0.387

1.081

0.794–1.472

0.620

1.042

0.751–1.455

0.804

 Stroke

42 (5.9%)

46 (7.8%)

1.580

1.032–2.420

0.031

1.360

0.875–2.112

0.170

1.305

0.832–2.047

0.236

Graft related outcomes at 10 year

           

 ITA graft failure†

172 (24.3%)

87 (19.0%)

0.711

0.549–0.925

0.009

0.767

0.592–0.994

0.045

0.708

0.536–0.935

0.013

 FitzGibbon grade B

22 (3.0%)

13 (2.9%)

0.813

0.407–1.642

0.556

0.899

0.451–1.791

0.762

0.922

0.437–1.980

0.832

 FitzGibbon grade O

149 (21.7%)

74 (16.6%)

0.695

0.526–0.918

0.010

0.752

0.568–0.996

0.046

0.685

0.511–0.919

0.011

 LITA graft failure

66 (8.6%)

38 (7.6%)

0.794

0.532–1.193

0.257

0.865

0.579–1.294

0.481

0.773

0.506–1.191

0.235

 RITA graft failure

115 (18.1%)

57 (13.4%)

0.696

0.507–0.957

0.025

0.726

0.528–0.999

0.049

0.703

0.504–0.981

0.038

  1. Data are expressed as numbers (%). Cumulative incidence of events was presented as Kaplan–Meier estimates
  2. DM diabetes mellitus, HR hazard ratio, CI confidence interval, NA not applicable, MACE major adverse cardiovascular event, ITA internal thoracic artery, LITA left internal thoracic artery, RITA right internal thoracic artery
  3. *Multivariable analysis was not performed for early clinical outcomes due to a small number of events
  4. †FitzGibbon grade A indicated that the graft was patent with ≤ 50% stenosis. FitzGibbon grade B indicated that the extent of graft stenosis was > 50% but not occluded. FitzGibbon grade O indicated total graft occlusion without contrast filling. Herein, graft failure was defined as FitzGibbon grade B or O
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Cardiovascular Diabetology

ISSN: 1475-2840