Fig. 3

Decision curve analysis showing clinical utility of using the three best-performing ML models according to all classification performance metrics. One top-performing logistic regression classifier operated on top-5 most discriminative features with the optimal cut-point value selected using the i) Index of Union (IoU) and ii) the closest to (0, 1) criteria (yellow line), whereas two operated on 10 principal components with the optimal cut-point value selected using i) Index of Union (IoU) and ii) the closest to (0, 1) criteria (violet line) method, and using iii) the Youden index method (green line)