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Table 3 Cox-proportional hazard model evaluating the association between NT-ProBNP levels and all-cause mortality according to baseline HbA1c levels

From: NT-ProBNP and mortality across the spectrum of glucose tolerance in the general US population

Population

NT-ProBNP (pg/ml)

All-cause mortality

HR

95% CI

p-value

Whole population

Per 1 SD

1.11

1.07–1.17

 < 0.001

 < 100

1.00

Ref.

 

100–299

1.61

1.12–2.32

0.012

 ≥ 300

2.96

1.75–5.00

 < 0.001

HbA1c < 5.7%

Per 1 SD

1.12

1.07–1.18

 < 0.001

 < 100

1.00

Ref.

 

100–299

1.72

1.00–2.95

0.050

 ≥ 300

3.12

1.50–6.49

0.003

HbA1c 5.7–6.4%

Per 1 SD

1.23

1.05–1.43

0.010

 < 100

1.00

Ref.

 

100–299

1.84

0.92–3.67

0.082

 ≥ 300

3.79

1.59–9.01

0.003

Diabetes

Per 1 SD

1.10

1.05–1.16

 < 0.001

 < 100

1.00

Ref.

 

100–299

1.44

0.81–2.56

0.206

 ≥ 300

2.43

0.98–6.06

0.056

  1. Covariates included in model were age, sex, race-ethnicity, body mass index, education, cigarette smoke, total cholesterol, eGFR, blood pressure category, prevalent cardiovascular disease and alcohol consumption
  2. CI confidence interval, NT-ProBNP N-terminal pro-B natriuretic peptide