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Table 4 Association of changes in MetS components with the risk of CHD, Tehran Lipid and Glucose Study

From: Gender differences in changes in metabolic syndrome status and its components and risk of cardiovascular disease: a longitudinal cohort study

 

Women (n = 2684)

 

Men (n = 1940)

 
   

Model 1

Model 2

   

Model 1

Model 2

 

Parameter

Events/n

Incidence

Rate per 1000

Person-Years

HR (95% CI)

HR (95% CI)

 

Events/n

Incidence

Rate per 1000

Person-Years

HR (95% CI)

HR (95% CI)

* Women-to-men RHR

High WC

          

High WC-free

67/1288

3.1 (2.4–3.9)

Reference

Reference

 

85/729

7.3 (5.9-9.0)

Reference

Reference

-

High WC-recovery

19/224

5.0 (3.2–7.9)

1.20 (0.72-2.00)

1.11 (0.66–1.87)

 

17/82

13.4 (8.3–21.6)

1.87 (1.11–3.14)

1.73 (1.03–2.92)

0.64 (0.30–1.33)

High WC-developed

18/223

4.8 (3.0-7.6)

1.29 (0.76–2.17)

1.19 (0.69–2.03)

 

24/202

7.4 (4.9–11.1)

1.03 (0.65–1.62)

0.96 (0.60–1.52)

1.23 (0.61–2.47)

High WC-stable

126/949

8.1 (6.8–9.6)

1.71 (1.27–2.31)

1.48 (1.03–2.12)

 

156/927

10.5 (9.0-12.3)

1.35 (1.04–1.76)

1.20 (0.88–1.65)

1.23 (0.82–1.83)

High FPG

          

High FPG-free

92/1796

3.0 (2.4–3.7)

Reference

Reference

 

159/1275

7.7 (6.6-9.0)

Reference

Reference

-

High FPG-recovery

13/166

4.7 (2.7–8.2)

1.19 (0.66–2.12)

1.00 (0.56–1.79)

 

18/152

7.1 (4.4–11.3)

0.72 (0.44–1.17)

0.69 (0.42–1.13)

1.44 (0.67–3.08)

High FPG-developed

17/156

6.4 (4.0-10.4)

1.82 (1.08–3.06)

1.61 (0.95–2.71)

 

23/163

8.8 (5.8–13.2)

0.97 (0.62–1.50)

0.91 (0.59–1.41)

1.76 (0.89–3.47)

High FPG-stable

108/566

12.1 (10.0-14.6)

2.76 (2.08–3.66)

2.20 (1.65–2.95)

 

82/350

15.5 (12.5–19.3)

1.50 (1.14–1.96)

1.36 (1.03–1.79)

1.62 (1.09–2.40)

High TG

          

High TG-free

46/1107

2.4 (1.8–3.2)

Reference

Reference

 

88/706

7.8 (6.3–9.6)

Reference

Reference

-

High TG-recovery

28/288

5.8 (4.1–8.5)

1.88 (1.18–3.01)

1.70 (1.06–2.74)

 

36/244

9.2 (6.6–12.8)

1.46 (0.99–2.16)

1.35 (0.91–2.01)

1.26 (0.68–2.32)

High TG-developed

27/319

5.1 (3.4–7.4)

1.71 (1.06–2.75)

1.57 (0.97–2.54)

 

30/199

9.4 (6.6–13.5)

1.36 (0.90–2.06)

1.23 (0.81–1.88)

1.27 (0.67–2.40)

High TG-stable

129/970

8.1 (6.8–9.7)

2.38 (1.69–3.34)

1.80 (1.26–2.56)

 

128/791

10.1 (8.5–12.1)

1.54 (1.18–2.03)

1.31 (0.98–1.75)

1.37 (0.88–2.13)

Low HDL

          

Low HDL-free

23/307

4.5 (3.0-6.8)

Reference

Reference

 

39/322

7.6 (5.6–10.5)

Reference

Reference

-

Low HDL-recovery

26/397

3.8 (2.6–5.7)

0.91 (0.52–1.59)

1.13 (0.73–1.75)

 

43/348

7.6 (5.6–10.3)

1.17 (0.76–1.81)

0.88 (0.50–1.54)

0.77 (0.37–1.57)

Low HDL-developed

13/149

5.3 (3.1–9.2)

1.19 (0.60–2.35)

1.17 (0.67–2.06)

 

18/129

8.9 (5.6–14.2)

1.33 (0.76–2.32)

1.09 (0.55–2.16)

0.93 (0.38–2.23)

Low HDL-stable

168/1831

5.5 (4.7–6.4)

1.27 (0.82–1.96)

1.27 (0.89–1.82)

 

182/1141

10.0 (8.6–11.5)

1.59 (1.12–2.24)

1.00 (0.64–1.56)

0.78 (0.44–1.37)

High BP

          

High BP-free

66/1605

2.4 (1.9-3.0)

Reference

Reference

 

108/1077

6.1 (5.1–7.4)

Reference

Reference

-

High BP-recovery

29/301

5.8 (4.1–8.4)

1.65 (1.06–2.56)

1.52 (0.97–2.37)

 

33/201

10.5 (7.5–14.9)

1.43 (0.96–2.11)

1.34 (0.91–1.99)

1.12 (0.62–2.03)

High BP-developed

21/222

5.7 (3.7–8.7)

1.72 (1.05–2.82)

1.50 (0.91–2.47)

 

41/231

11.1 (8.2–15.1)

1.34 (0.93–1.93)

1.41 (0.98–2.04)

1.06 (0.57–1.95)

High BP-stable

114/556

13.1 (10.9–15.8)

3.02 (2.19–4.16)

2.43 (1.75–3.39)

 

100/431

15.3 (12.6–18.7)

1.54 (1.16–2.05)

1.49 (1.11-2.00)

1.62 (1.07–2.47)

  1. Model 1: Adjusted for age, Model 2: Adjusted for age, smoking status, physical activity level, education, marital status, family history of CVD, body mass index + other components of MetS.
  2. *Women to men RHR: The value shows women-to-men relative hazard ratio for each parameter obtained in model 2. MetS: metabolic syndrome; CVD: cardiovascular diseases; CI: confidence interval; HR: hazard ratio; RHR: ratio of hazard ratios; BP: blood pressure; FPG: fasting plasma glucose; TG: Triglycerides; HDL-C: high-density lipoprotein cholesterol; WC; waist circumference