Skip to main content

Table 3 Association of changes in MetS components with the risk of CVD, Tehran Lipid and Glucose Study

From: Gender differences in changes in metabolic syndrome status and its components and risk of cardiovascular disease: a longitudinal cohort study

 

Women (n = 2684)

 

Men (n = 1940)

 
   

Model 1

Model 2

   

Model 1

Model 2

 

Parameter

Events/n

Incidence

Rate per 1000

Person-Years

HR (95% CI)

HR (95% CI)

 

Events/n

Incidence

Rate per 1000

Person-Years

HR (95% CI)

HR (95% CI)

* Women-to-men RHR

High WC

          

High WC-free

82/1288

3.8 (3.1–4.7)

Reference

Reference

 

100/729

8.6 (7.0-10.5)

Reference

Reference

-

High WC-recovery

26/224

6.9 (4.7–10.2)

1.30 (0.83–2.02)

1.16 (0.74–1.82)

 

18/82

14.4 (9.0-22.8)

1.69 (1.03–2.80)

1.54 (0.93–2.56)

0.75 (0.38–1.47)

High WC-developed

20/223

5.3 (3.4–8.3)

1.13 (0.69–1.84)

0.98 (0.59–1.61)

 

30/202

9.3 (6.5–13.3)

1.09 (0.72–1.64)

0.99 (0.65–1.51)

0.98 (0.51–1.86)

High WC-stable

164/949

10.6 (9.1–12.4)

1.74 (1.33–2.28)

1.35 (0.98–1.87)

 

179/927

12.1 (10.5–14.1)

1.31 (1.02–1.67)

1.07 (0.80–1.43)

1.26 (0.87–1.82)

High FPG

          

High FPG-free

125/1796

4.1 (3.4–4.9)

Reference

Reference

 

180/1275

8.8 (7.6–10.1)

Reference

Reference

-

High FPG-recovery

17/166

6.2 (3.9–10.1)

1.11 (0.67–1.84)

0.95 (0.57–1.58)

 

20/152

7.9 (5.1–12.3)

0.68 (0.43–1.08)

0.65 (0.41–1.04)

1.44 (0.72–2.87)

High FPG-developed

17/156

6.4 (4.0-10.4)

1.30 (0.78–2.15)

1.15 (0.69–1.91)

 

29/163

11.2 (7.7–16.1)

1.05 (0.71–1.55)

0.98 (0.66–1.45)

1.16 (0.61–2.22)

High FPG-stable

133/566

15.0 (12.6–17.8)

2.39 (1.86–3.06)

1.89 (1.46–2.45)

 

98/350

18.8 (15.4–23.0)

1.55 (1.21–1.99)

1.41 (1.09–1.81)

1.34 (0.94–1.91)

High TG

          

High TG-free

62/1107

3.3 (2.5–4.2)

Reference

Reference

 

114/706

10.2 (8.4–12.2)

Reference

Reference

-

High TG-recovery

39/288

8.2 (6.0-11.3)

1.92 (1.28–2.86)

1.76 (1.18–2.64)

 

37/244

9.5 (6.9–13.1)

1.20 (0.83–1.74)

1.10 (0.75–1.60)

1.60 (0.92–2.78)

High TG-developed

33/319

6.2 (4.4–8.8)

1.51 (0.99–2.30)

1.44 (0.94–2.21)

 

32/199

10.0 (7.1–14.2)

1.12 (0.76–1.66)

1.02 (0.69–1.52)

1.41 (0.79–2.51)

High TG-stable

158/970

10.1 (8.6–11.7)

2.09 (1.55–2.81)

1.60 (1.17–2.19)

 

144/791

11.5 (9.7–13.5)

1.37 (1.07–1.76)

1.17 (0.90–1.52)

1.37 (0.92–2.02)

Low HDL

          

Low HDL-free

32/307

6.3 (4.4–8.9)

Reference

Reference

 

50/322

9.8 (7.4–13.0)

Reference

Reference

-

Low HDL-recovery

38/397

5.7 (4.1–7.8)

0.98 (0.61–1.56)

0.96 (0.60–1.55)

 

51/348

9.1 (6.9–11.9)

1.11 (0.75–1.64)

1.10 (0.74–1.62)

0.87 (0.47–1.62)

Low HDL-developed

14/149

5.8 (3.4–9.8)

0.93 (0.50–1.75)

0.89 (0.47–1.67)

 

23/129

11.6 (7.7–17.5)

1.37 (0.84–2.25)

1.25 (0.76–2.06)

0.70 (0.31–1.57)

Low HDL-stable

208/1831

6.8 (6.0-7.8)

1.14 (0.79–1.66)

0.94 (0.64–1.38)

 

203/1141

11.2 (9.7–12.8)

1.42 (1.04–1.93)

1.17 (0.85–1.62)

0.80 (0.49–1.30)

High BP

          

High BP-free

75/1605

2.7 (2.1–3.4)

Reference

Reference

 

117/1077

6.6 (5.5–7.9)

Reference

Reference

-

High BP-recovery

40/301

8.1 (6.0-11.1)

1.92 (1.30–2.83)

1.77 (1.19–2.61)

 

39/201

12.6 (9.2–17.2)

1.53 (1.06–2.20)

1.45 (1.01–2.09)

1.21 (0.71–2.06)

High BP-developed

32/222

8.8 (6.2–12.4)

2.25 (1.48–3.41)

1.98 (1.30–3.01)

 

45/231

12.2 (9.1–16.4)

1.29 (0.91–1.83)

1.34 (0.94–1.90)

1.47 (0.86–2.53)

High BP-stable

145/556

16.8 (14.3–19.8)

3.15 (2.35–4.23)

2.55 (1.88–3.45)

 

126/431

19.6 (16.0-23.3)

1.72 (1.32–2.23)

1.65 (1.26–2.16)

1.54 (1.05–2.26)

  1. Model 1: Adjusted for age, Model 2: Adjusted for age, smoking status, physical activity level, education, marital status, family history of CVD, body mass index + other components of MetS.
  2. *Women to men RHR: The value shows women-to-men relative hazard ratio for each parameter obtained in model 2. MetS: metabolic syndrome; CVD: cardiovascular diseases; CI: confidence interval; HR: hazard ratio; RHR: ratio of hazard ratios; BP: blood pressure; FPG: fasting plasma glucose; TG: Triglycerides; HDL-C: high-density lipoprotein cholesterol; WC; waist circumference