Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis

Table 3 Summary of Findings (SoF) with the GRADE system (case‒control/cross‒sectional studies)

The level of triglyceride glucose index in people with cerebrovascular diseases compared with without cerebrovascular diseases.
Population: Subjects with cerebrovascular diseases vs. normal subjects.
Settings: Eight studies were conducted in Asia, two studies were conducted in Europe.
Cases: Subjects with cerebrovascular diseases.
Controls: normal subjects.
Outcomes	OR (95% CI)^a	No of participants (studies)	Quality of the evidence Comments (GRADE)
Risk of cerebrovascular diseases	1.15(1.07,1.23)	305,808 (10 case‒control /cross‒sectional studies)	⊕⊕⊕ MODERATE ^b

GRADE working group grades of evidence
High quality: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
Abbreviations: CI, confidence interval; OR, odds ratio
^a Results for triglyceride glucose index levels of subjects with cerebrovascular diseases compared with controls
^b Upgraded by one level because triglyceride glucose index was associated with cerebrovascular diseases and all the results of the included studies were almost identical (subjects with cerebrovascular diseases had higher triglyceride glucose index)
GRADE, Grading of Recommendations Assessment, Development and Evaluation system;
⊕, quality of evidence

ISSN: 1475-2840