Association between triglyceride glucose index and risk of cerebrovascular disease: systematic review and meta-analysis

Table 2 Summary of Findings (SoF) with the GRADE system (cohort studies)

High level of triglyceride glucose index compared with low level triglyceride glucose index in risk of cerebrovascular diseases.
Population: Subjects with high level of triglyceride glucose index vs. low level triglyceride glucose index.
Settings: Thirteen studies were conducted in Asia, one study were conducted in Europe.
Cases: Subjects with high level of triglyceride glucose index.
Controls: Subjects with low level of triglyceride glucose index.
Outcomes	RR/HR (95% CI)^a	No of participants (studies)	Quality of the evidence Comments (GRADE)
Risk of cerebrovascular diseases	1.22(1.14,1.30)	11,644,261 (19cohort studies)	⊕⊕⊕⊕ HIGH ^b,c

GRADE working group grades of evidence
High quality: We are very confident that the true effect lies close to that of the estimate of the effect
Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different
Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect
Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect
Abbreviations: CI, confidence interval; RR/HR, relative risk/hazard ratio
^a Results for cerebrovascular diseases risk of subjects with higher levels of triglyceride glucose index compared with lower triglyceride glucose index
^b Upgraded by one level due to all the results of the included studies were almost consistent (subjects with high triglyceride glucose index had high risk of cerebrovascular diseases)
^c Upgraded by one level due to a dose‒response relationship between cerebrovascular disease and triglyceride glucose index (The higher triglyceride glucose index, the higher risk of cerebrovascular diseases)
GRADE, Grading of Recommendations Assessment, Development and Evaluation system;
⊕, quality of evidence

ISSN: 1475-2840