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Table 3 Association between baseline TyG and incident heart failure in the Kailuan cohort

From: Triglyceride-glucose index and the risk of heart failure: Evidence from two large cohorts and a mendelian randomization analysis

 

Q1

Q2

Q3

Q4

P for trend

Per 1-unit increment

P value

Number of patients

23,997

24,000

24,001

23,998

   

HF cases

497

576

729

924

   

Persons

23,997

24,000

24,001

23,998

   

Person-years

297,098

295,908

294,857

292,552

   

HF incidence 1

1.67(1.53–1.83)

1.95(1.79–2.11)

2.47(2.30–2.66)

3.16(2.96–3.37)

   

Model 1 2

1

1.16(1.03–1.31)

1.48(1.32–1.66)

1.90(1.70–2.11)

< 0.001

1.44(1.37–1.51)

< 0.001

Model 2 3

1

1.12(1.00-1.27)

1.41(1.26–1.58)

1.90(1.70–2.12)

< 0.001

1.47(1.40–1.55)

< 0.001

Model 3 4

1

1.00(0.88–1.12)

1.12(1.00-1.26)

1.23(1.09–1.39)

< 0.001

1.17(1.10–1.24)

< 0.001

Sensitivity analysis

Sensitivity analysis 1 5

1

1.00(0.88–1.13)

1.14(1.01–1.28)

1.23(1.10–1.41)

< 0.001

1.18(1.10–1.25)

< 0.001

Sensitivity analysis 2 6

1

0.97(0.84–1.11)

1.11(0.98–1.27)

1.17(1.02–1.34)

0.006

1.13(1.06–1.22)

< 0.001

Competing risk regression 7

1

1.01(0.90–1.14)

1.14(1.02–1.29)

1.25(1.10–1.41)

< 0.001

1.18(1.10–1.25)

< 0.001

  1. 1 HF incidence; The incidence rates per 1000 person years with the corresponding 95% confidence intervals are shown
  2. 2 Model 1: Unadjusted. The hazard ratios with the corresponding 95% confidence intervals are shown
  3. 3 Model 2: Age-sex adjusted. The hazard ratios with the corresponding 95% confidence intervals are shown
  4. 4 Model 3: Adjusted for age, gender, education, income, physical activity, smoking status, alcohol intake, diabetes, LDL-c, HDL-c, SBP, DBP, BMI, eGFR, hs-CRP, anti-hypertensive drugs, anti-diabetes drugs, and lipid-lowering drugs. The hazard ratios with the corresponding 95% confidence intervals are shown
  5. 5 Sensitivity analysis 1: exclude follow-up time less than 2 years, remained 95,275 subjects with 2,497 HF cases. The hazard ratios with the corresponding 95% confidence intervals are shown
  6. 6 Sensitivity analysis 2: exclude subjects with medication at baseline (anti-hypertension drugs, lipid lower drugs, anti-diabetes drugs), remained 85,118 subjects with 2,118 HF cases. The hazard ratios with the corresponding 95% confidence intervals are shown
  7. 7 Competing risk regression: sub-hazard ratios with the corresponding 95% confidence intervals are shown