Fig. 4
Mendelian randomization (MR) association between genetically determined TyG index and HF. Sensitivity analysis 1: MR analysis through IVW method in SNPs pruned by linkage disequilibrium with R2 < 0.001 Sensitivity analysis 2: Multivariable MR through IVW method after adjusting for cofounders including BMI, SBP, DBP, LDL-c, HDL-c, and DM. Sensitivity analysis 3: MR analysis through IVW method after excluding any SNPs significantly associated with those confounders, including BMI, SBP, DBP, LDL-c, HDL-c, and DM.
Abbreviations: SNPs: single-nucleotide polymorphisms; OR: odds ratio; IVW: inverse-variance weighted