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Table 2 Association of Δmetabolites with incident CVD

From: Response of circulating metabolites to an oral glucose challenge and risk of cardiovascular disease and mortality in the community

 

Δ metabolites

Fasting metabolites

Model 1

Model 2

Model 1

Model 2

Metabolite

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

HR (95% CI)

P-value

Glutamate

1.22 (1.02–1.47)

0.033

1.24 (1.03–1.5)

0.026

1.15 (0.96–1.37)

0.13

1.13 (0.93–1.36)

0.22

Deoxycholate

1.13 (0.93–1.37)

0.21

1.26 (1.02–1.55)

0.030

1.02 (0.84–1.23)

0.84

1.05 (0.87–1.27)

0.61

LPC 18:2

0.82 (0.67–1.00)

0.056

0.80 (0.65–0.99)

0.037

0.79 (0.63–0.99)

0.041

0.84 (0.66–1.07)

0.15

Inosine

0.93 (0.77–1.13)

0.47

0.82 (0.67–0.99)

0.043

1.07 (0.88–1.29)

0.49

0.97 (0.80–1.18)

0.78

TAG 58:12

1.24 (1.03–1.49)

0.023

1.20 (1.00–1.43)

0.052

1.22 (1.01–1.46)

0.034

1.17 (0.96–1.42)

0.12

TAG 50:2

1.32 (1.08–1.61)

0.007

1.22 (0.99–1.51)

0.07

1.30 (1.08–1.57)

0.005

1.11 (0.90–1.36)

0.33

Lactate

0.81 (0.67–0.97)

0.026

0.84 (0.69–1.02)

0.08

1.11 (0.93–1.34)

0.25

1.10 (0.91–1.33)

0.32

Isoleucine

1.20 (1.00–1.43)

0.046

1.16 (0.97–1.38)

0.12

1.06 (0.88–1.28)

0.55

0.96 (0.78–1.18)

0.69

Cholesterol ester 20:5

0.82 (0.68–0.98)

0.032

0.87 (0.72–1.04)

0.13

0.93 (0.78–1.10)

0.39

1.00 (0.83–1.22)

0.97

TAG 48:1

1.25 (1.04–1.51)

0.018

1.17 (0.96–1.43)

0.13

1.24 (1.03–1.49)

0.022

1.06 (0.87–1.30)

0.55

TAG 50:3

1.27 (1.04–1.54)

0.017

1.16 (0.95–1.43)

0.14

1.24 (1.03–1.50)

0.025

1.05 (0.84–1.32)

0.67

Alanine

0.80 (0.66–0.97)

0.024

0.86 (0.70–1.05)

0.15

1.00 (0.83–1.21)

0.97

0.95 (0.78–1.16)

0.61

Aminoisobutyric

1.20 (1.00–1.43)

0.044

1.13 (0.94–1.36)

0.18

0.97 (0.81–1.16)

0.74

1.04 (0.87–1.25)

0.64

Gentisate

0.82 (0.68–0.99)

0.038

0.90 (0.74–1.09)

0.27

0.85 (0.70–1.04)

0.11

0.83 (0.68–1.01)

0.06

TAG 54:3

1.21 (1.01–1.45)

0.040

1.11 (0.91–1.34)

0.29

1.18 (0.99–1.41)

0.07

1.01 (0.82–1.25)

0.92

TAG 48:2

1.21 (1.00–1.45)

0.046

1.11 (0.91–1.35)

0.32

1.21 (1.01–1.45)

0.041

1.03 (0.83–1.28)

0.78

  1. Δ Metabolite is the log2 fold-change from pre- to post-OGTT and baseline metabolites were log-transformed. Baseline and change metabolite values were standardized (mean 0 and SD 1)
  2. The hazard ratio (HR) represents the relative hazard for a 1-SD higher log2 fold-change in the metabolite
  3. P-values are not adjusted for multiple hypothesis testing. Values in bold represent statistically significant associations at a P < 0.05 level
  4. The Δ metabolite models are also adjusted for fasting metabolite levels
  5. Model 1 is adjusted for age and sex
  6. Model 2 is adjusted also for BMI, smoking, hypertension treatment, systolic blood pressure, and total/HDL cholesterol