| Δ metabolites | Fasting metabolites | ||||||
---|---|---|---|---|---|---|---|---|
Model 1 | Model 2 | Model 1 | Model 2 | |||||
Metabolite | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
Glutamate | 1.22 (1.02–1.47) | 0.033 | 1.24 (1.03–1.5) | 0.026 | 1.15 (0.96–1.37) | 0.13 | 1.13 (0.93–1.36) | 0.22 |
Deoxycholate | 1.13 (0.93–1.37) | 0.21 | 1.26 (1.02–1.55) | 0.030 | 1.02 (0.84–1.23) | 0.84 | 1.05 (0.87–1.27) | 0.61 |
LPC 18:2 | 0.82 (0.67–1.00) | 0.056 | 0.80 (0.65–0.99) | 0.037 | 0.79 (0.63–0.99) | 0.041 | 0.84 (0.66–1.07) | 0.15 |
Inosine | 0.93 (0.77–1.13) | 0.47 | 0.82 (0.67–0.99) | 0.043 | 1.07 (0.88–1.29) | 0.49 | 0.97 (0.80–1.18) | 0.78 |
TAG 58:12 | 1.24 (1.03–1.49) | 0.023 | 1.20 (1.00–1.43) | 0.052 | 1.22 (1.01–1.46) | 0.034 | 1.17 (0.96–1.42) | 0.12 |
TAG 50:2 | 1.32 (1.08–1.61) | 0.007 | 1.22 (0.99–1.51) | 0.07 | 1.30 (1.08–1.57) | 0.005 | 1.11 (0.90–1.36) | 0.33 |
Lactate | 0.81 (0.67–0.97) | 0.026 | 0.84 (0.69–1.02) | 0.08 | 1.11 (0.93–1.34) | 0.25 | 1.10 (0.91–1.33) | 0.32 |
Isoleucine | 1.20 (1.00–1.43) | 0.046 | 1.16 (0.97–1.38) | 0.12 | 1.06 (0.88–1.28) | 0.55 | 0.96 (0.78–1.18) | 0.69 |
Cholesterol ester 20:5 | 0.82 (0.68–0.98) | 0.032 | 0.87 (0.72–1.04) | 0.13 | 0.93 (0.78–1.10) | 0.39 | 1.00 (0.83–1.22) | 0.97 |
TAG 48:1 | 1.25 (1.04–1.51) | 0.018 | 1.17 (0.96–1.43) | 0.13 | 1.24 (1.03–1.49) | 0.022 | 1.06 (0.87–1.30) | 0.55 |
TAG 50:3 | 1.27 (1.04–1.54) | 0.017 | 1.16 (0.95–1.43) | 0.14 | 1.24 (1.03–1.50) | 0.025 | 1.05 (0.84–1.32) | 0.67 |
Alanine | 0.80 (0.66–0.97) | 0.024 | 0.86 (0.70–1.05) | 0.15 | 1.00 (0.83–1.21) | 0.97 | 0.95 (0.78–1.16) | 0.61 |
Aminoisobutyric | 1.20 (1.00–1.43) | 0.044 | 1.13 (0.94–1.36) | 0.18 | 0.97 (0.81–1.16) | 0.74 | 1.04 (0.87–1.25) | 0.64 |
Gentisate | 0.82 (0.68–0.99) | 0.038 | 0.90 (0.74–1.09) | 0.27 | 0.85 (0.70–1.04) | 0.11 | 0.83 (0.68–1.01) | 0.06 |
TAG 54:3 | 1.21 (1.01–1.45) | 0.040 | 1.11 (0.91–1.34) | 0.29 | 1.18 (0.99–1.41) | 0.07 | 1.01 (0.82–1.25) | 0.92 |
TAG 48:2 | 1.21 (1.00–1.45) | 0.046 | 1.11 (0.91–1.35) | 0.32 | 1.21 (1.01–1.45) | 0.041 | 1.03 (0.83–1.28) | 0.78 |