Fig. 2

Clinical and subclinical correlates of Δmetabolites. Partial correlations (Spearman; adjusted for age, sex, and fasting metabolite level) of Δmetabolites (log2[post/pre] metabolite level) with clinical and subclinical measures are displayed. Carotid-femoral pulse wave velocity, coronary artery calcium, subcutaneous and visceral adipose tissue measures are from the 7th examination cycle (sample sizes shown in Table 1 footnote). All other measures were assessed contemporaneously with metabolites (5th examination cycle). Carotid-femoral pulse wave velocity was expressed as −1000/value, HOMA-iR was log-transformed, and coronary artery calcium was analyzed as the natural log of (value + 1). The area of each circle is proportional to the magnitude of the correlation coefficient and the circle color reflects the magnitude and direction of the correlation coefficient. Overlain “X” indicated that the correlation is not statistically significant at the P < 0.05 level