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Table 5 Echocardiographic parameters of the study participants in Part 2 stratified by baseline serum TSP2 tertiles (N = 146)

From: Prospective associations of circulating thrombospondin-2 level with heart failure hospitalization, left ventricular remodeling and diastolic function in type 2 diabetes

 

First and second

serum TSP2 tertiles

(N = 98)

Third

serum TSP2 tertile

(N = 48)

p-value

IVSd (mm)

   

Baseline

10.62 ± 1.79

11.05 ± 2.22

0.22

Follow-up

11.19 ± 1.82

11.91 ± 2.18

0.05

Change

0.57 ± 1.28

0.86 ± 1.23

0.20

LVPWd (mm)

   

Baseline

9.07 ± 1.10

9.65 ± 1.51

< 0.05

Follow-up

9.41 ± 1.40

9.85 ± 1.69

0.10

Change

0.32 ± 1.43

0.19 ± 1.41

0.61

LVM (g)

   

Baseline

145.19 ± 37.75

161.46 ± 48.82

< 0.05

Follow-up

153.60 ± 40.27

168.53 ± 48.76

0.05

Change

8.41 ± 13.68

7.06 ± 14.07

0.58

LVEF (%)

   

Baseline

66.13 ± 3.72

64.99 ± 4.40

0.12

Follow-up

64.38 ± 4.45

62.62 ± 4.63

< 0.05

Change

−1.75 ± 5.33

−2.49 ± 5.32

0.45

E/A

   

Baseline

0.91 ± 0.24

1.02 ± 0.63

0.13

Follow-up

0.84 ± 0.19

0.91 ± 0.39

0.27

Change

−0.07 ± 0.21

−0.04 ± 0.21

0.51

e’ septal (cm/s)

   

Baseline

7.62 ± 1.91

7.54 ± 2.17

0.83

Follow-up

7.12 ± 1.76

6.63 ± 2.07

0.14

Change

−0.47 ± 2.00

−0.92 ± 1.66

0.18

e’ lateral (cm/s)

   

Baseline

10.23 ± 2.34

10.13 ± 2.94

0.83

Follow-up

9.51 ± 2.18

8.90 ± 2.54

0.13

Change

−0.77 ± 1.87

−1.23 ± 1.78

0.16

Average E/e’

   

Baseline

8.74 ± 2.36

9.53 ± 3.45

0.16

Follow-up

9.36 ± 2.70

11.00 ± 3.75

< 0.01

Change

0.57 ± 2.09

1.48 ± 2.35

< 0.05

LAVi (ml/m2)

   

Baseline

30.22 ± 8.23

32.42 ± 10.28

0.19

Follow-up

28.82 ± 7.98

33.78 ± 10.80

< 0.01

Change

−1.32 ± 7.35

2.09 ± 8.90

< 0.05

  1. TSP2, thrombospondin-2; A wave, trans-mitral late diastolic peak velocity; E wave, trans-mitral early diastolic peak velocity; e’, early diastolic peak velocity of mitral valve at septal or lateral annulus; IVSd, inter-ventricular septal dimension at end-diastole; LAVi, left atrial volume index; LV, left ventricular; LVEF, LV ejection fraction; LVPWd, LV posterior wall thickness at end-diastole