Skip to main content

Table 2 Multivariable Cox regression analysis showing the associations of serum TSP2 level and other clinical variables with incident HHF (N = 4949)

From: Prospective associations of circulating thrombospondin-2 level with heart failure hospitalization, left ventricular remodeling and diastolic function in type 2 diabetes

Baseline variables

HR (95% CI)

p-value

 

Men

1.04 (0.80–1.35)

0.795

 

Age, years

1.04 (1.03–1.06)

< 0.001

 

Duration of T2D, years

1.02 (1.00-1.03)

0.034

 

Ever smoker, %

1.13 (0.86–1.48)

0.375

 

BMI kg/m2

1.04 (1.02–1.07)

0.003

 

Systolic BP, mmHg

1.008 (1.003–1.010)

0.009

 

Dyslipidemia

1.41 (0.82–2.40)

0.211

 

Atrial fibrillation

1.96 (1.44–2.67)

< 0.001

 

CVD

1.25 (0.99–1.58)

0.058

 

HbA1c, %

1.14 (1.05–1.23)

< 0.001

 

eGFR, mL/min/1.73m2

0.98 (0.979–0.99)

< 0.001

 

Albuminuria

2.18 (1.65–2.88)

< 0.001

 

hsCRP*, mg/dL

1.06 (0.97–1.16)

0.212

 

TSP2*, ng/mL

1.27 (1.03–1.58)

0.028

 
  1. *Log-transformed before analysis
  2. HR, Hazard Ratio; CI, Confidence Interval; TSP2, thrombospondin-2; HHF, hospitalization for heart failure; BMI, body mass index; BP, Blood Pressure; CVD, cardiovascular diseases; HbA1c, glycated hemoglobin; eGFR, estimated glomerular filtration rate; hsCRP, high-sensitivity C-reactive protein
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840