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Table 4 Binomial negative regression models to identify factors associated with the subclinical carotid atherosclerosis burden in subjects with T1D.

From: Association of α-klotho with subclinical carotid atherosclerosis in subjects with type 1 diabetes mellitus

 

Model 1

Model 2

Model 3

Predictors

IRR

95% CI

IRR

95% CI

IRR

95% CI

α-klotho (log scale)

1.40 *

1.06–1.86

1.41 *

1.06–1.89

1.41 *

1.06–1.89

Sex (women)

0.57

0.33–0.97

0.54 *

0.31–0.95

0.55 *

0.31–0.97

Age

1.08 ‡

1.05–1.11

1.08 ‡

1.05–1.11

1.08 ‡

1.05–1.11

sBP

1.00

0.98–1.01

1.00

0.99–1.01

1.00

0.99–1.01

BMI

1.04

0.98–1.11

1.04

0.98–1.11

1.04

0.98–1.11

Smoker

2.39 †

1.37–4.22

2.28 †

1.29–4.07

2.29 †

1.28–4.13

Former smoker

0.96

0.49–1.82

0.98

0.51–1.85

1.00

0.52–1.88

Hypertension

1.71

0.98–3.02

1.65

0.93–2.93

1.65

0.93–2.92

Dyslipidemia

1.53

0.93–2.55

1.62

0.95–2.80

1.60

0.94–2.77

ACR

1.01 ‡

1.00-1.02

1.02 †

1.01–1.03

1.02 †

1.00-1.03

Calcium

  

0.93

0.47–1.88

0.95

0.47–1.94

Phosphate

  

1.15

0.73–1.83

1.13

0.71–1.81

PTH

  

0.94

0.80–1.10

0.93

0.79–1.10

FGF23

    

1.00

1.00–1.00

Vitamin D

    

1.00

0.98–1.01

Observations

225

 

225

 

225

 

R2 Nagelkerke

0.574

 

0.578

 

0.580

 
  1. Association measure expressed by Incidence rate ratio (IRR) and 95% confidence interval (95% CI). ACR, Albuminuria-to-creatinine ratio; BMI, body mass index; FGF23, fibroblastic growth factor 23; PTH, parathyroid hormone; sBP, systolic blood pressure; Vitamin D, 25-hydroxyvitamin D
  2. * p < 0.05; † p < 0.01; ‡ p < 0.001