Fig. 3
From: The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians
Comparison of percent (%) changes of protein levels in response to hypoglycemia in two different prospective studies in T2D subjects. Line graphs showing changes as percentage of six platelet activation related proteins, Platelet glycoprotein VI (A) Plasminogen activator inhibitor 1 (PAI-1) (B), Tissue factor (C), Soluble CD-40 ligand (D), Von Willebrand factor (E), D-Dimer (F) from baseline (BL) to hypoglycemia and to 24 h post-hypoglycemia in study 1 (open blue square) and study 2 (open blue circle). Baseline protein levels were normalized to 1 to show the % change from baseline to subsequent timepoints. Platelet glycoprotein VI and Plasminogen activator inhibitor 1 (PAI-1) showed a significant differential percentage change from BL to hypoglycemia. Tissue factor and Soluble CD-40 ligand showed a significant differential percentage change from BL to hypoglycemia and from BL to 24 h post-hypoglycemia as well. Von Willebrand factor and D-Dimer showed significant differential percentage change from BL to 24 h post-hypoglycemia only. Two-way arrows in the graphs indicate the duration of hypoglycemia for study 1. Data are presented here as mean % Change of proteins ± SEM. $p < 0.01, % change of BL to hypo between study 2 vs. study 1 in T2D; &p < 0.05, % change of BL to 24 h post-hypoglycemia between study 2 vs. study 1 in T2D. BL, baseline; Hypo, hypoglycemia