Fig. 2
From: The severity and duration of Hypoglycemia affect platelet-derived protein responses in Caucasians
Comparison of percent (%) changes of protein levels in response to hypoglycemia in two different prospective studies in CONTROL subjects. Line graphs showing changes as percentage of six platelet activation related proteins, Plasminogen activator inhibitor 1 (PAI-1) (A) Soluble CD-40 ligand (B), Vitamin K-dependent protein S (C), Von Willebrand factor (D), Plasminogen (E), D-Dimer (F) from baseline (BL) to hypoglycemia and to 24 h post-hypoglycemia in study 1 (open white square) and study 2 (open white circle). Baseline protein levels were normalized to 1 to show the % change from baseline to subsequent timepoints. PAI-1 and soluble CD-40 ligand showed a significant differential percentage change from BL to hypoglycemia. Vitamin K-dependent protein S and Von Willebrand factor showed a significant differential percentage change from BL to hypoglycemia and from BL to 24 h post-hypoglycemia as well. Plasminogen and D-Dimer showed significant differential percentage change from BL to 24 h post-hypoglycemia only. Two-way arrows in the graphs indicate the duration of hypoglycemia for study 1. Data are presented here as mean % Change of proteins ± SEM. *p < 0.01, ***p < 0.001, % change of BL to hypo between study 2 vs. study 1 in control; #p < 0.05, ###p < 0.001, % change of BL to 24 h post-hypoglycemia between study 2 vs. study 1 in control. BL, baseline; Hypo, hypoglycemia