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Table 3 Association of the concordance/discordance groups with atherosclerosis in coronary, intra- and extracranial arteries

From: Association between triglyceride glucose index and atherosclerotic plaques and Burden: findings from a community-based study

Atherosclerotic plaque

TyG /HOMA-IR

n/N (%)

Model1*

Model2†

OR/cOR(95%CI)

P

OR/cOR(95%CI)

P

Presence of intracranial plaque

Low TyG /Low HOMA-IR

122/944(12.92)

Reference

 

Reference

 

Low TyG /High HOMA-IR

60/415(14.42)

1.2(0.85–1.68)

0.30

0.98(0.68–1.42)

0.93

High TyG /Low HOMA-IR

73/416(17.59)

1.45(1.05-2.00)

0.02

1.31(0.94–1.82)

0.11

High TyG /High HOMA-IR

177/944(18.75)

1.66(1.29–2.15)

< 0.001

1.28(0.95–1.71)

0.10

Intracranial atherosclerotic burden‡

Low TyG /Low HOMA-IR

-

Reference

 

Reference

 

Low TyG /High HOMA-IR

-

1.19(0.85–1.67)

0.31

0.99(0.69–1.42)

0.96

High TyG /Low HOMA-IR

-

1.47(1.07–2.02)

0.02

1.31(0.94–1.82)

0.11

High TyG /High HOMA-IR

-

1.66(1.28–2.14)

< 0.001

1.26(0.94–1.68)

0.12

Presence of extracranial plaque

Low TyG /Low HOMA-IR

308/944(32.63)

Reference

 

Reference

 

Low TyG /High HOMA-IR

134/415(32.21)

1.11(0.87–1.43)

0.40

1.10(0.85–1.44)

0.47

High TyG /Low HOMA-IR

173/416(41.69)

1.39(1.09–1.77)

0.007

1.34(1.04–1.71)

0.02

High TyG /High HOMA-IR

360/944(38.14)

1.39(1.14–1.68)

< 0.001

1.35(1.08–1.68)

< 0.001

Extracranial atherosclerotic burden§

Low TyG /Low HOMA-IR

-

Reference

 

Reference

 

Low TyG /High HOMA-IR

-

1.15(0.90–1.47)

0.28

1.14(0.88–1.48)

0.33

High TyG /Low HOMA-IR

-

1.40(1.10–1.76)

0.005

1.35(1.06–1.71)

0.02

High TyG /High HOMA-IR

-

1.40(1.16–1.69)

< 0.001

1.38(1.11–1.71)

< 0.001

Presence of coronary plaque

Low TyG /Low HOMA-IR

354/944(37.50)

Reference

 

Reference

 

Low TyG /High HOMA-IR

164/415(39.42)

1.29(1.001–1.66)

0.049

1.08(0.82–1.42)

0.58

High TyG /Low HOMA-IR

195/416(46.99)

1.46(1.14–1.86)

0.003

1.30(1.01–1.68)

0.04

High TyG /High HOMA-IR

447/944(47.35)

1.78(1.46–2.16)

< 0.001

1.40(1.12–1.75)

< 0.001

Segment stenosis score||

Low TyG /Low HOMA-IR

-

Reference

 

Reference

 

Low TyG /High HOMA-IR

-

1.25(0.97–1.61)

0.08

1.11(0.85–1.45)

0.44

High TyG /Low HOMA-IR

-

1.47(1.16–1.88)

0.001

1.39(1.09–1.78)

0.009

High TyG /High HOMA-IR

-

1.65(1.36-2.00)

< 0.001

1.39(1.11–1.73)

0.004

  1. ORs were estimated for the presence of intracranial, extracranial and coronary plaque; cORs were used for Intra-/extra-cranial atherosclerotic burden and segment stenosis score
  2. HOMA-IR, homeostasis model assessment insulin resistance; TyG, the triglyceride glucose index
  3. *Model 1: adjusted for age, sex, current smoking and current drinking;
  4. †Model 2: adjusted for age, sex, current smoking, current drinking, BMI, estimated glomerular filtration rate, low-density lipoprotein levels, medical history of transient ischemia attack, stroke, coronary disease, hypertension and dyslipidemia, using of antihypertensive and antiplatelet medications
  5. ‡ The intracranial atherosclerosis burden was graded according to the sum of intracranial atherosclerosis scores, including 0, 1, 2–3 and ≥ 4 scores
  6. § The extracranial atherosclerosis burden was graded according to the sum of extracranial atherosclerosis scores, including 0, 1, 2–3 and ≥ 4 scores
  7. || Segment stenosis score, the total number of segments with any plaque was graded: 0, 1–3, and ≥ 4 scores
  8. The TyG index and HOMA-IR were divided into high and low groups by using median as cut-off value. Median TyG: 8.76; median HOMA-IR: 1.55