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Table 2 Association of the TyG index/HOMA-IR with atherosclerosis in coronary, intra- and extracranial arteries

From: Association between triglyceride glucose index and atherosclerotic plaques and Burden: findings from a community-based study

Atherosclerotic plaque

The TyG index

 

HOMA-IR

 

n/N (%)

Model1*

OR/cOR(95%CI)

P

Model2†

OR/cOR(95%CI)

P

 

n/N (%)

Model1*

OR/cOR(95%CI)

P

Model2†

OR/cOR(95%CI)

P

Presence of intracranial plaque

           

T1

113/906(12.5)

Reference

 

Reference

  

128/906(14.1)

Reference

 

Reference

 

T2

148/907(16.3)

1.42(1.09–1.85)

0.01

1.27(0.96–1.68)

0.10

 

136/904(15.0)

1.16(0.89–1.52)

0.28

0.96(0.72–1.27)

0.75

T3

171/906(18.9)

1.75(1.34–2.27)

< 0.001

1.45(1.09–1.92)

0.01

 

168/909(18.5)

1.49(1.15–1.94)

0.003

1.06(0.78–1.45)

0.69

Pre 1-SD

-

1.26(1.14–1.40)

< 0.001

1.19(1.06–1.33)

0.003

 

-

1.13(1.03–1.24)

0.01

1.01(0.91–1.13)

0.82

P for trend

-

 

< 0.001

 

0.01

 

-

 

0.002

 

0.58

Intracranial atherosclerotic burden‡

           

T1

-

Reference

 

Reference

  

-

Reference

 

Reference

 

T2

-

1.39(1.06–1.81)

0.02

1.22(0.92–1.61)

0.16

 

-

1.16(0.89–1.52)

0.27

0.95(0.71–1.26)

0.70

T3

-

1.73(1.33–2.24)

< 0.001

1.40(1.06–1.85)

0.02

 

-

1.49(1.15–1.93)

0.003

1.05(0.78–1.43)

0.74

Pre 1-SD

-

1.25(1.13–1.39)

< 0.001

1.16(1.04–1.30)

0.009

 

-

1.12(1.02–1.22)

0.014

0.999(0.89–1.12)

0.98

P for trend

-

 

< 0.001

 

0.02

 

-

 

0.002

 

0.61

Presence of extracranial plaque

           

T1

285/906(31.5)

Reference

 

Reference

  

315/906(34.8)

Reference

 

Reference

 

T2

353/907(38.9)

1.43(1.18–1.74)

< 0.001

1.30(1.06–1.60)

0.01

 

329/904(36.4)

1.23(1.01–1.51)

0.04

1.17(0.95–1.45)

0.14

T3

337/906(37.2)

1.33(1.09–1.62)

0.005

1.25(1.01–1.55)

0.04

 

331/909(36.4)

1.28(1.05–1.56)

0.02

1.24(0.98–1.57)

0.07

Pre 1-SD

-

1.13(1.04–1.22)

0.003

1.12(1.02–1.22)

0.01

 

-

1.03(0.95–1.11)

0.49

1.01(0.92–1.10)

0.90

P for trend

-

 

0.007

 

0.052

 

-

 

0.03

 

0.09

Extracranial atherosclerotic burden§

           

T1

-

Reference

 

Reference

  

-

Reference

 

Reference

 

T2

-

1.43(1.18–1.73)

< 0.001

1.31(1.07–1.60)

0.008

 

-

1.27(1.04–1.54)

0.02

1.22(0.99–1.49)

0.06

T3

-

1.34(1.11–1.63)

0.003

1.28(1.04–1.58)

0.02

 

-

1.29(1.06–1.57)

0.01

1.27(1.01–1.60)

0.04

Pre 1-SD

-

1.14(1.05–1.23)

0.001

1.13(1.04–1.23)

0.004

 

-

1.03(0.96–1.11)

0.44

1.01(0.93–1.10)

0.80

P for trend

-

 

0.004

 

0.03

 

-

 

0.02

 

0.06

Presence of coronary plaque

           

T1

328/906(36.2)

Reference

 

Reference

  

356/906(39.3)

Reference

 

Reference

 

T2

414/907(45.6)

1.63(1.33–1.99)

< 0.001

1.40(1.13–1.72)

0.002

 

378/904(41.8)

1.36(1.11–1.67)

0.003

1.16(0.94–1.44)

0.17

T3

418/906(46.1)

1.72(1.41–2.09)

< 0.001

1.42(1.14–1.76)

0.002

 

426/909(46.9)

1.75(1.43–2.15)

< 0.001

1.33(1.05–1.69)

0.02

Pre 1-SD

-

1.22(1.12–1.32)

< 0.001

1.14(1.04–1.24)

0.002

 

-

1.25(1.13–1.37)

< 0.001

1.10(0.99–1.21)

0.08

P for trend

-

 

< 0.001

 

0.002

 

-

 

< 0.001

 

0.02

Segment stenosis score||

           

T1

-

Reference

 

Reference

  

-

Reference

 

Reference

 

T2

-

1.36(1.12–1.66)

0.002

1.23(1.004–1.52)

0.046

 

-

1.34(1.10–1.64)

0.004

1.21(0.98–1.49)

0.08

T3

-

1.62(1.33–1.97)

< 0.001

1.40(1.14–1.73)

0.002

 

-

1.62(1.33–1.98)

< 0.001

1.30(1.03–1.65)

0.03

Pre 1-SD

-

1.20(1.11–1.30)

< 0.001

1.14(1.05–1.24)

0.002

 

-

1.20(1.11–1.31)

< 0.001

1.11(1.02–1.21)

0.01

P for trend

-

 

< 0.001

 

0.002

 

-

 

< 0.001

 

0.04

  1. ORs were estimated for the presence of intracranial, extracranial and coronary plaque; cORs were used for intra-/extra-cranial atherosclerotic burden and segment stenosis score
  2. HOMA-IR, homeostasis model assessment insulin resistance; TyG, the triglyceride glucose index
  3. *Model 1: adjusted for age, sex, current smoking and current drinking;
  4. †Model 2: adjusted for age, sex, current smoking, current drinking, BMI, estimated glomerular filtration rate, low-density lipoprotein levels, medical history of TIA, stroke, coronary disease, hypertension and dyslipidemia, using of antihypertensive and antiplatelet medications
  5. ‡ The intracranial atherosclerosis burden was graded according to the sum of intracranial atherosclerosis scores, including 0, 1, 2–3 and ≥ 4 scores
  6. § The extracranial atherosclerosis burden was graded according to the sum of extracranial atherosclerosis scores, including 0, 1, 2–3 and ≥ 4 scores
  7. || Segment stenosis score, the total number of segments with any plaque was graded: 0, 1–3, and ≥ 4 scores
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Cardiovascular Diabetology

ISSN: 1475-2840