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Table 1 Demographics of long COVID patients and controls

From: Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system

Demographics

Median age of healthy individuals (n = 29)

52 [41–57]

Median age of long COVID (high responders) (n = 66)

51 [40–60]

Median age of long COVID (low responders) (n = 24)

45 [31–58]

Serum Ferritin (µg L−1)

P-value (Mann–Whitney U test; unpaired non-parametric data expressed as median [Q1–Q3] of high responders)

0.80

Median of healthy individuals (n = 29)

120 [40–230]

Median of long COVID (63 of 66) high-responder patients

107 [61.0–179.5]

Median of long COVID of the low responder patients (24 of 24) patients. [p-Value = 0.36]

74 [33.5–153.5]

Interleukin-6 (pg ml−1)

P-value (Mann–Whitney U test; unpaired non-parametric data expressed as median [Q1 – Q3] of high responders)

0.04

Median of healthy individuals (28 of 29 samples)

1.9 [1.1–2.5]

Median of long COVID (63 of 66) high-responder patients

2.3 [1.5–3.5]

Mean of long COVID of the low responder patients (24 of 24 patients) [p-Value = 0.65]

1.9 [± 0.6]

Hospitalization (percentage / %)

Yes

21

No

72

Unknown

7

WHO severity (percentage / %)

Mild

71

Moderate

5

Severe

17

Unknown

7

Co-morbidities of long COVID patients (N = 99) versus our healthy controls (N = 29)

Co-morbidity

% in 99 long Covid patients

% in 29

control patients

Hypertension

24

24

Hyperlipidaemia

19

24

Type 2 diabetes mellitus

6

0

Rosacea

4

3

Thrombosis (previous blood clots)

3

0

Cardiovascular disease

3

3

Psoriasis

2

3

Rheumatoid arthritis

2

0

Previous stroke

1

3

Previous myocardial infarction

1

0

Lingering symptoms in long COVID patients (N = 99)

Duration of symptoms from diagnosis to taking of blood samples (days:) 221 ± 99

Lingering symptoms

% in 99 long Covid patients

Constant fatigue

74

Cognitive impairment (“brain fog” / forgetfulness / poor concentration)

71

Dyspnoea

59

Arthralgia / myalgia

49

Sleep disturbance

34

Depression / anxiety

30

Heart rate dysfunction / palpitations

30

Recurring chest pain

29

Anosmia (loss of smell)

25

Dysgeusia (loss of taste)

25

Low oxygen levels

13

  1. All data were subjected to Shapiro-Wilks normality tests. An unpaired T-test was performed on parametric data with the data expressed as mean ± standard deviation. whereas the Mann–Whitney U test was used on unpaired non-parametric data and the data expressed as median [Q1–Q3] (all two-tailed)