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Table 3 Associations of cumulative accumulation and slope of the TyG index with CVD and all-cause mortality

From: Time course of the triglyceride glucose index accumulation with the risk of cardiovascular disease and all-cause mortality

Outcomes

CumTyG < median, slope ≥ 0

CumTyG < median, slope < 0

CumTyG ≥ median, slope ≥ 0

CumTyG ≥ median, slope < 0

P for trend

CVD

 Cases, n (%)

701 (4.89)

629 (5.46)

1144 (8.20)

1128 (9.46)

 

 Incidence rate per

1000 person-years

5.52 (5.13–5.95)

6.22 (5.75–6.73)

9.98 (9.42–10.60)

11.60 (11.00-12.30)

 

 Model 1

Reference

1.13 (1.01–1.26)

1.82 (1.66-2.00)

2.13 (1.93–2.34)

< 0.0001

 Model 2

Reference

1.07 (0.96–1.19)

1.53 (1.39–1.68)

1.67 (1.52–1.84)

< 0.0001

 Model 3

Reference

1.03 (0.86–1.07)

1.34 (1.21–1.47)

1.37 (1.24–1.51)

< 0.0001

All-cause mortality

 Cases, n (%)

575 (4.01)

594 (5.15)

983 (7.05)

1013 (8.50)

 

 Incidence rate per

1000 person-years

4.44 (4.09–4.82)

5.74 (5.30–6.22)

8.27 (7.77–8.81)

10.00 (9.41–10.60)

 

 Model 1

Reference

1.29 (1.15–1.45)

1.85 (1.67–2.05)

2.24 (2.02–2.48)

< 0.0001

 Model 2

Reference

1.15 (1.03–1.29)

1.26 (1.13–1.40)

1.36 (1.22–1.51)

< 0.0001

 Model 3

Reference

1.07 (0.95–1.20)

1.24 (1.11–1.38)

1.28 (1.15–1.43)

< 0.0001

  1. Model 1: unadjusted
  2. Model 2: adjusted for age and sex
  3. Model 3: further adjusted for education, income, physical activity, smoking status, drinking status, history of hypertension, diabetes, dyslipidemia, antihypertensive agents, antidiabetic agents, lipid-lowering agents, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, estimated glomerular filtration rate, and high sensitivity C reactive protein
  4. The median value of cumTyG was 34.44 × year