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Table 2 Association of time course of cumTyG accumulation with risk of CVD and all-cause morality

From: Time course of the triglyceride glucose index accumulation with the risk of cardiovascular disease and all-cause mortality

 

Slopea

cumTyG06-08

 

cumTyG08-10b

 

< 0

≥ 0

P value

HR (95% CI)

P value

HR (95% CI)

P value

CVD

 Cases, n (%)

1757 (7.49)

1845 (6.52)

     

 Incidence rate per

1000 person-years

8.86(8.46–9.29)

7.64(7.30–7.99)

     

 Model 1

1.16(1.09–1.24)

Reference

< 0.0001

1.05(1.04–1.06)

< 0.0001

1.03(0.98–1.05)

0.1078

 Model 2

1.15(1.08–1.23)

Reference

< 0.0001

1.05(1.05–1.06)

< 0.0001

1.03(0.98–1.04)

0.1120

 Model 3

1.11(1.04–1.19)

Reference

0.0014

1.04(1.03–1.04)

< 0.0001

1.02(0.96–1.03)

0.3251

All-cause mortality

 Cases, n (%)

1607 (6.85)

1558 (5.51)

     

 Incidence rate per

1000 person-years

7.85(7.48–8.25)

6.28(5.97–6.59)

     

 Model 1

1.25(1.17–1.34)

Reference

< 0.0001

1.07(1.07–1.08)

< 0.0001

1.05(0.99–1.08)

0.0864

 Model 2

1.24(1.15–1.33)

Reference

< 0.0001

1.07(1.06–1.08)

< 0.0001

1.05(0.98–1.08)

0.1052

 Model 3

1.18(1.10–1.26)

Reference

< 0.0001

1.06(1.05–1.07)

< 0.0001

1.03(0.97–1.05)

0.4097

  1. Model 1: unadjusted
  2. Model 2: adjusted for age and sex
  3. Model 3: further adjusted for education, income, physical activity, smoking status, drinking status, history of hypertension, diabetes, dyslipidemia, antihypertensive agents, antidiabetic agents, lipid-lowering agents, body mass index, systolic blood pressure, diastolic blood pressure, total cholesterol, estimated glomerular filtration rate, and high sensitivity C reactive protein
  4. CI confidence interval, CVD cardiovascular disease, cumTyG cumulative triglyceride glucose index, HR hazard ratio
  5. a further adjusted for mean TyG during 2006–2010
  6. b further adjusted for cumulative TyG during 2006–2008