Table 1 Baseline characteristics according to cumulative accumulation and slope of the TyG index
Characteristics | Overall (N = 51,734) | CumTyG < median, slope ≥ 0 (N = 14,340) | CumTyG < median, slope < 0 (N = 11,527) | CumTyG ≥ median, slope ≥ 0 (N = 13,944) | CumTyG ≥ median, slope < 0 (N = 11,923) | P value |
|---|---|---|---|---|---|---|
Age, years | 48.76 ± 11.77 | 44.79 ± 10.92 | 46.84 ± 11.00 | 51.01 ± 11.88 | 52.79 ± 11.44 | < 0.0001 |
Men, n (%) | 39,387 (76.13) | 10,690 (74.55) | 8787 (76.23) | 10,597 (76.00) | 9313 (78.11) | < 0.0001 |
High school or above, n (%) | 4187 (8.38) | 1189 (8.59) | 772 (6.89) | 1260 (9.40) | 966 (8.38) | < 0.0001 |
Income ≥ 1000RMB, n (%) | 7751 (15.53) | 2090 (15.11) | 1256 (11.22) | 2433 (18.19) | 1972 (17.12) | < 0.0001 |
Current smoker, n (%) | 17,476 (34.72) | 5030 (36.08) | 3570 (31.62) | 4899 (36.31) | 3977 (34.25) | < 0.0001 |
Current alcohol, n (%) | 20,243 (40.2) | 5747 (41.22) | 3957 (35.03) | 5781 (42.84) | 4758 (40.94) | < 0.0001 |
Active physical activity, n (%) | 6979 (13.49) | 1346 (9.39) | 1067 (9.26) | 2362 (16.94) | 2204 (18.49) | < 0.0001 |
Hypertension, n (%) | 19,650 (37.98) | 4106 (28.63) | 4373 (37.94) | 5513 (39.54) | 5658 (47.45) | < 0.0001 |
Diabetes mellitus, n (%) | 4044 (7.82) | 331 (2.31) | 656 (5.69) | 1154 (8.28) | 1903 (15.96) | < 0.0001 |
Dyslipidemia, n (%) | 17,472 (33.77) | 2444 (17.04) | 3304 (28.66) | 5161 (37.01) | 6563 (55.04) | < 0.0001 |
Antihypertensive agents, n (%) | 4311 (8.33) | 633 (4.41) | 543 (4.71) | 1634 (11.72) | 1501 (12.59) | < 0.0001 |
Hypoglycemic agents, n (%) | 953 (1.84) | 84 (0.59) | 93 (0.81) | 348 (2.50) | 428 (3.59) | < 0.0001 |
Lipid-lowering agents, n (%) | 404 (0.78) | 50 (0.35) | 29 (0.25) | 178 (1.28) | 147 (1.23) | < 0.0001 |
Body mass index, kg/m2 | 25.04 ± 3.48 | 24.36 ± 3.42 | 24.76 ± 3.47 | 25.39 ± 3.43 | 25.73 ± 3.43 | < 0.0001 |
SBP, mmHg | 127.90 ± 19.64 | 123.44 ± 18.06 | 127.37 ± 19.53 | 129.13 ± 19.79 | 132.34 ± 20.22 | < 0.0001 |
DBP, mmHg | 82.37 ± 11.29 | 80.41 ± 10.82 | 82.68 ± 11.46 | 82.57 ± 11.23 | 84.2 ± 11.40 | < 0.0001 |
FBG, mmol/L | 5.38 ± 1.52 | 4.98 ± 0.85 | 5.31 ± 1.27 | 5.36 ± 1.37 | 5.96 ± 2.19 | < 0.0001 |
Total cholesterol, mmol/L | 4.91 ± 1.12 | 4.78 ± 0.94 | 4.79 ± 1.13 | 5.07 ± 1.08 | 5.02 ± 1.32 | < 0.0001 |
Triglyceride, mmol/L | 1.67 ± 1.37 | 1.01 ± 0.52 | 1.62 ± 1.10 | 1.64 ± 1.20 | 2.56 ± 1.91 | < 0.0001 |
LDL cholesterol, mmol/L | 2.29 ± 0.90 | 2.23 ± 0.88 | 2.29 ± 0.86 | 2.3 ± 0.92 | 2.34 ± 0.92 | < 0.0001 |
HDL cholesterol, mmol/L | 1.55 ± 0.39 | 1.55 ± 0.38 | 1.58 ± 0.38 | 1.52 ± 0.40 | 1.55 ± 0.41 | < 0.0001 |
eGFR, mL/min/1.73 m2 | 84.31 ± 25.11 | 88.1 ± 24.42 | 82.45 ± 26.15 | 85.65 ± 25.57 | 80.00 ± 23.48 | < 0.0001 |
hs-CRP, mg/L | 2.30 ± 6.51 | 2.23 ± 5.75 | 2.06 ± 6.67 | 2.57 ± 8.11 | 2.28 ± 4.89 | < 0.0001 |
CumTyG, ×years | 35.09 ± 4.72 | 31.59 ± 2.01 | 31.65 ± 2.07 | 38.59 ± 3.90 | 38.52 ± 4.18 | < 0.0001 |
Slope, year− 1 | 0.01 ± 0.16 | 0.11 ± 0.10 | − 0.11 ± 0.09 | 0.13 ± 0.11 | − 0.12 ± 0.11 | < 0.0001 |