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Table 2 Summary of multiple Cox regression analysis of each biomarker and the combined ‘cardiac score’ for the prediction of survival in T2DM patients

From: Prognostic value of soluble ST2, high-sensitivity cardiac troponin, and NT-proBNP in type 2 diabetes: a 15-year retrospective study

Variable

 

N

Crude

Adjusted

Multimarker

HR (95% CI)

HR (95% CI)

HR (95% CI)

Group of sST2

Low

57

Ref.

Ref.

Ref.

Intermediate

464

2.82 (1.45–5.52)

2.00 (1.02–3.94)

2.06 (1.04–4.06)

High

40

3.77 (1.69–8.38)

2.76 (1.20–6.33)

2.34 (1.02–5.40)

Group of hs-cTnI

Low

130

Ref.

Ref.

Ref.

Intermediate

232

1.73 (1.10–2.70)

1.25 (0.78–1.99)

1.27 (0.79–2.03)

High

199

3.20 (2.08–4.93)

1.63 (1.01–2.62)

1.33 (0.81–2.18)

Group of NT-proBNP

Low

347

Ref.

Ref.

Ref.

Intermediate

152

2.36 (1.72–3.23)

1.48 (1.05–2.10)

1.40 (0.98–1.99)

High

62

5.47 (3.78–7.90)

2.94 (1.90–4.55)

2.76 (1.74–4.40)

Group of ‘cardiac score’

3–4

130

Ref.

Ref.

5–7

375

2.74 (1.72–4.39)

1.79 (1.09–2.91)

8–9

56

9.58 (5.60–16.40)

3.61 (1.95–6.68)

‘Cardiac score’

  

1.66 (1.49–1.85)

1.35 (1.19–1.53)

  1. Crude, adjusted (for sex, age, smoking status, hypertension, T2DM duration, BMI, HbA1c, blood lipids, eGFR, and hs-CRP), and multimarker hazard ratios (HR) with 95% confidence intervals are shown. Significant predictors are in bold. For the calculation of the ‘cardiac score’ the reader is referred to the Materials and Methods section