Fig. 3

Comparisons of effects of genetically proxied GK activation and genetically predicted lower HbA_1c. All estimations were based on the inverse variance weighted method. The population was restricted to European ancestry. 1% lower HbA_1c equals to 11 mmol/mol lower. OR, odds ratio; CI, confidence interval; GK, glucokinase; SNP, single-nucleotide polymorphism; T2D, type 2 diabetes; CAD, coronary artery disease; HF, heart failure