Fig. 2

Associations of genetically proxied GK activation with risks of CAD, HF, PAD and stroke. The population was restricted to European ancestry. All estimations were based on the inverse variance weighted method. 1% lower HbA_1c equals to 11 mmol/mol lower. OR, odds ratio; CI, confidence interval; GK, glucokinase; SNP, single-nucleotide polymorphism; CAD, coronary artery disease; HF, heart failure; PAD, peripheral arterial disease