Fig. 1From: Anti-obesity therapy for cardiovascular disease prevention: potential expected roles of glucagon-like peptide-1 receptor agonistsRequisites of anti-obesity drugs for ORCVD prevention. Of the three ideal conditions for anti-obesity drugs to prevent ORCVDs, GLP-1RAs appear to have advantages over conventional drugs and biguanide derivatives in terms of the degree of weight loss (especially semaglutide) and specific cardiovascular effects. *Mainly semaglutide and liraglutide. **Orlistat, phentermine-topiramate, and naltrexone-bupropion. †Mainly metformin. CV, cardiovascular; GLP-1RAs, glucagon-like peptide-1 receptor agonists; MACE, major adverse cardiovascular events; ORCVD, obesity-related cardiovascular disease; STEP, Semaglutide Treatment Effect in People with ObesityBack to article page