Table 1 The characteristics of the patients who were prescribed gabapentin and comparison drugs for long term before and after propensity-score matching for covariates of deep venous thrombosis
From: Cardiovascular risk of gabapentin and pregabalin in patients with diabetic neuropathy
Characteristics | Before matching | After matching | ||||
|---|---|---|---|---|---|---|
Cohort, No. (%) | Cohort, No. (%) | |||||
Gabapentin | Comparison | SMD | Gabapentin | Comparison | SMD | |
Cohort size | 38,603 | 8359 | Â | 7050 | 7050 | Â |
Age at Index | 60.5 ± 12.3 | 62.8 ± 12.5 | 0.19* | 61.5 ± 11.7 | 62.2 ± 12.5 | 0.06 |
Female | 54.0 | 61.7 | 0.16* | 63.5 | 61.6 | 0.04 |
Race and ethnicity | ||||||
 White | 64.7 | 72.7 | 0.17* | 70.9 | 71.7 | 0.02 |
 African American | 26.5 | 16.4 | 0.25* | 19.4 | 17.6 | 0.05 |
 Unknown Race | 7.0 | 9.5 | 0.09 | 8.5 | 9.3 | 0.03 |
 Hispanic or Latino | 9.5 | 5.9 | 0.13* | 6.4 | 6.5 | 0.01 |
 Asian | 1.2 | 0.8 | 0.04 | 0.7 | 0.8 | 0.01 |
Cardiovascular risk factors | ||||||
 Hypertensive diseases | 85.0 | 87.4 | 0.07 | 86.9 | 87.1 | 0.01 |
 Obesity | 40.1 | 47.2 | 0.14* | 47.3 | 47.1 | 0.00 |
 High cholesterol | 23.1 | 28.6 | 0.13* | 28.0 | 28.1 | 0.00 |
 Obstructive sleep apnea | 18.0 | 24.5 | 0.16* | 24.4 | 23.9 | 0.01 |
 Tobacco use | 4.1 | 6.7 | 0.11* | 5.9 | 6.5 | 0.03 |
 Pre-existing heart failure | 17.8 | 20.0 | 0.06 | 19.1 | 20.1 | 0.02 |
 Pre-existing peripheral vascular disease | 14.4 | 14.3 | 0.00 | 14.3 | 14.1 | 0.01 |
 End stage renal disease | 4.5 | 4.3 | 0.01 | 3.8 | 4.2 | 0.02 |
 Alcohol abuse | 4.0 | 3.7 | 0.01 | 4.1 | 3.8 | 0.01 |
 Long term use of NSAID | 1.4 | 2.6 | 0.09 | 2.0 | 2.3 | 0.02 |
 Adverse socioeconomic circumstances | 4.6 | 7.6 | 0.12* | 6.7 | 7.5 | 0.03 |
Initial use | ||||||
 Postherpetic neuralgia | 0.6 | 0.4 | 0.03 | 0.5 | 0.5 | 0.01 |
 Fibromyalgia | 11.7 | 14.0 | 0.07 | 15.7 | 14.6 | 0.03 |
 Pain | 9.5 | 11.7 | 0.07 | 11.2 | 11.8 | 0.02 |
 Restless legs syndrome | 4.4 | 4.9 | 0.03 | 5.5 | 5.0 | 0.02 |
 Epilepsy and recurrent seizures | 2.7 | 6.3 | 0.17* | 5.3 | 5.7 | 0.02 |
 Neuralgia and neuritis, unspecified | 4.7 | 4.1 | 0.03 | 4.5 | 4.3 | 0.01 |
Specific risk factor of deep venous thrombosis | ||||||
 Pre-existing deep venous thrombosis | 2.9 | 3.6 | 0.04 | 3.4 | 3.5 | 0.01 |
 Cancer | 1.2 | 2.0 | 0.07 | 1.8 | 2.0 | 0.01 |
 Inflammatory bowel disease | 0.4 | 0.6 | 0.03 | 0.5 | 0.6 | 0.02 |