Table 1 Definitions of variables according to ICD-10 codes and anatomical therapeutic chemical groups
| Â | ICD-10 codes or ATC groups |
|---|---|
Exclusion criteria | Â |
Preexisting diabetes | ICD-10: E10-E14, O240-O243, O245, O249 and/or ATC: A10 (except A10BA02) (≥ 2 redemptions) |
Preexisting cardiovascular disease (CVD) | ICD-10: I00-I09, I20-I99, G45-G46 and/or ATC: C01, B01 (≥ 2 redemptions) |
Exposure | Â |
Gestational diabetes mellitus (GDM) | ICD-10: O244 |
Outcomes | Â |
Any cardiovascular and metabolic morbidity defined as any of: | Â |
 Dyslipidemia | ICD-10: E78 (and no preexisting dyslipidemia (see below)) |
 Hypertension | ICD-10: I10-I15 (and no preexisting hypertension (see below)) |
 Ischemic heart disease | ICD-10: I20-I25 |
 Pulmonary embolism | ICD-10: I26 |
 Cardiac arrhythmia | ICD-10: I48, I490 |
 Heart failure | ICD-10: I50 |
 Stroke/transient cerebral ischemia (TCI) | ICD-10: I61, I63-I66, G45-G46 |
 Other venous thrombosis | ICD-10: I80-I82 |
 Antithrombotic agents | ATC: B01 (≥ 2 redemptions) |
 Lipid modifying agents | ATC: C10 (≥ 2 redemptions) |
 Antihypertensive agents | ATC: C02-C03, C07-C09 (≥ 2 redemptions) |
Major CVD defined as any of: | Â |
 Ischemic heart disease | ICD-10: I20-I25 |
 Heart failure | ICD-10: I50 |
 Stroke/TCI | ICD-10: I61, I63-I66, G45-G46 |
Hypertension | ICD-10: I10- I15 and/or ATC: C02-C03, C07-C09 (≥ 2 redemptions) and no preexisting hypertension (see below) |
Dyslipidemia | ICD-10: E78 and/or ATC: C10 (≥ 2 redemptions) and no preexisting dyslipidemia (see below) |
Venous thrombosis | ICD-10: I26, I80-I82 |
Potential confounders | At or 2Â years before index date |
Preexisting dyslipidemia | ICD-10: E78 and/or ATC: C10 (≥ 2 redemptions) |
Preexisting hypertension | ICD-10: I10-I15 (from 2 years before index date until gestational week 20) and/or ATC: C02-C03, C07-C09 (≥ 2 redemptions from 2 years before index date until gestational week 20) |
Preexisting polycystic ovary syndrome | ICD-10: E282 |
Preexisting hirsutism | ICD-10: L680 |
Preexisting metformin | ATC: A10BA02 (≥ 2 redemptions) |
Risk factors for outcome | In index pregnancy unless stated otherwise |
Preeclampsia | ICD-10: O14 (after gestational week 20) |
Gestational hypertension | ICD-10: O13, O16 (after gestational week 20) |
Potential intermediate covariates | Â |
Insulin treatment (in any GDM pregnancy) | ICD-10: O244E and/or ATC: A10A (≥ 1 redemption in ≥ 1 GDM pregnancy) |
Incident subsequent diabetes prior to outcome | ICD-10: E10-E14, O240-O243, O245, O249 and/or ATC: A10 (≥ 2 redemptions) and no incident outcome prior to incident diabetes |