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Fig. 4 | Cardiovascular Diabetology

Fig. 4

From: Tirzepatide, a dual GIP/GLP-1 receptor co-agonist for the treatment of type 2 diabetes with unmatched effectiveness regrading glycaemic control and body weight reduction

Fig. 4

Effects of tirzepatide on adjudicated cardiovascular events in SURPASS-4 [18] (A), a clinical trial recruiting subjects at high risk for cardiovascular events, and across the clinical trial program (phases 2 and 3) for tirzepatide [20] (B). MACE: Major adverse cardiovascular events. The line of identity (red, dashed) indicates an equal risk for CV events for tirzepatide and comparator(s). The blue, dashed line marks a hazard ratio of 1.3. An upper bound of the confidence interval for composite endpoints (MACE-3 and MACE-4, but not for individual endpoints) below 1.3 conventionally is interpreted as indicating a cardiovascular risk, which is not significantly elevated in comparison to the comparator(s). Comparators include placebo, insulin degludec, insulin glargine, dulaglutide 1.5 mg/week, and semaglutide 1.0 mg/week (GLP-1 receptor agonists). The numbers of patients at risk and the numbers of events observed are presented. The asterisk indicates a significant difference indirectly inferred from the 95% confidence interval completely being below the line of identity (= 1)

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Cardiovascular Diabetology

ISSN: 1475-2840