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Fig. 2 | Cardiovascular Diabetology

Fig. 2

From: Transitioning to active-controlled trials to evaluate cardiovascular safety and efficacy of medications for type 2 diabetes

Fig. 2

Demonstrating Preservation of 50% Efficacy of Dulaglutide. HR hazard ratio, IT investigational treatment. The simulation study showed a probability of 0.997 for tirzepatide to preserve 50% of dulaglutide efficacy. Therefore, due to the conservative choice of M1 margin and large sample size of SURPASS CVOT, a NI margin of 1.05 in the SURPASS CVOT will not only demonstrate NI of tirzepatide to dulaglutide, but also superiority of tirzepatide to a putative placebo

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