Fig. 2From: Transitioning to active-controlled trials to evaluate cardiovascular safety and efficacy of medications for type 2 diabetesDemonstrating Preservation of 50% Efficacy of Dulaglutide. HR hazard ratio, IT investigational treatment. The simulation study showed a probability of 0.997 for tirzepatide to preserve 50% of dulaglutide efficacy. Therefore, due to the conservative choice of M1 margin and large sample size of SURPASS CVOT, a NI margin of 1.05 in the SURPASS CVOT will not only demonstrate NI of tirzepatide to dulaglutide, but also superiority of tirzepatide to a putative placeboBack to article page