Association of the cumulative triglyceride-glucose index with major adverse cardiovascular events in patients with type 2 diabetes

Table 3 Incremental predictive value of the cumulative TyG index

	C statistics		NRI		IDI
	Estimate (95% CI)	P	Estimate (95% CI), %	P	Estimate (95% CI), %	P
MACEs
Conventional model	0.6864 (0.66–0.71)		Ref.		Ref.
Conventional model + cumulative TyG index	0.6937 (0.67–0.72)	0.032	6.90 (0.80–12.30)	0.02	0.50 (0.1–1.10)	< 0.001
CVD death
Conventional model	0.7247 (0.69–0.76)		Ref.		Ref.
Conventional model + cumulative TyG index	0.7292 (0.69–0.77)	0.368	4.10 (− 2.4–13.20)	0.09	4.00 (0.00–1.70)	< 0.001
Non-fatal MI
Conventional model	0.6808 (0.64–0.72)		Ref.		Ref.
Conventional model + cumulative TyG index	0.6895 (0.65–0.73)	0.118	12.60 (0.70–19.70)	0.03	0.40 (0.00–1.20)	0.02
Non-fatal stroke
Conventional model	0.6704 (0.62–0.72)		Ref.		Ref.
Conventional model + cumulative TyG index	0.6723 (0.63–0.72)	0.5421	5.00 (− 6.10 to 14.50)	0.289	0.00 (− 0.10 to 0.60)	0.507

The conventional model was adjusted for age, sex, education level, race, smoking status, drinking status, years of hypertension diagnosis, years of diabetes diagnosis, depression, body mass index, systolic blood pressure, diastolic blood pressure, heart rate, history of CVD, plasma total cholesterol, HbA1c, LDL-C, eGFR, statin, insulin, non-dihydropyridine calcium channel blockers, dihydropyridine calcium channel blockers, thiazolidinediones, and thiazide diuretics treatment at the baseline level
The bold values indicate that comparison between groups with significant statistical significance (P value < 0.05)
CI confidence interval, CVD cardiovascular disease, IDI integrated discrimination improvement, MACEs major adverse cardiovascular events, MI myocardial infarction, NRI net reclassification index, TyG index triglyceride-glucose index

ISSN: 1475-2840