Skip to main content

Table 2 Risk of incident MACEs and individual outcomes for the cumulative TyG index

From: Association of the cumulative triglyceride-glucose index with major adverse cardiovascular events in patients with type 2 diabetes

Cumulative TyG index

Events/No. at risk

Unadjusted

Model 1

Model 2

Model 3

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

HR (95% CI)

P value

MACEs

 Low

132/1292

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Moderate

169/1255

1.32 (1.05–1.66)

0.016

1.26 (0.96–1.66)

0.095

1.25 (0.94–1.65)

0.122

1.24 (0.94–1.64)

0.136

 High

171/1253

1.34 (1.07–1.69)

0.011

1.39 (1.05–1.83)

0.019

1.37 (1.02–1.83)

0.035

1.38 (1.03–1.86)

0.030

 Very high

201/1,222

1.63 (1.31–2.03)

< 0.001

1.62 (1.23–2.15)

0.001

1.58 (1.16–2.13)

0.003

1.59 (1.17–2.16)

0.003

 P for trend

  

< 0.001

 

< 0.001

 

< 0.001

 

< 0.001

CVD death

 Low

51/1424

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Moderate

70/1424

1.40 (0.97–2.01)

0.069

1.40 (0.89–2.20)

0.142

1.32 (0.84–2.09)

0.235

1.32 (0.84–2.08)

0.235

 High

56/1424

1.11 (0.76–1.63)

0.577

1.37 (0.86–2.18)

0.183

1.34 (0.82–2.17)

0.240

1.31 (0.80–2.13)

0.281

 Very high

79/1423

1.63 (1.14–2.31)

0.007

2.05 (1.29–3.26)

0.002

1.92 (1.16–3.16)

0.011

1.97 (1.19–3.26)

0.008

 P for trend

  

0.028

 

0.004

 

0.016

 

0.017

Non-fatal MI

 Low

46/1424

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Moderate

73/1424

1.64 (1.14–2.37)

0.008

1.59 (1.03–2.46)

0.037

1.58 (1.01–2.46)

0.044

1.64 (1.05–2.57)

0.030

 High

75/1424

1.68 (1.16–2.42)

0.006

1.64 (1.05–2.57)

0.030

1.55 (0.97–2.49)

0.066

1.61 (1.00–2.59)

0.049

 Very high

94/1423

2.17 (1.52–3.09)

< 0.001

1.69 (1.08–2.63)

0.021

1.66 (1.03–2.68)

0.039

1.66 (1.02–2.70)

0.041

 P for trend

  

< 0.001

 

0.002

 

0.005

 

0.004

Non-fatal stroke

 Low

47/1424

Ref.

 

Ref.

 

Ref.

 

Ref.

 

 Moderate

43/1424

0.94 (0.62–1.41)

0.751

0.98 (0.60–1.60)

0.930

1.01 (0.61–1.65)

0.979

0.97 (0.58–1.60)

0.891

 High

59/1424

1.29 (0.88–1.90)

0.187

1.30 (0.81–2.07)

0.277

1.30 (0.80–2.12)

0.290

1.29 (0.79–2.12)

0.312

 Very high

48/1423

1.08 (0.72–1.61)

0.707

1.23 (0.75–2.02)

0.409

1.26 (0.73–2.17)

0.416

1.29 (0.75–2.23)

0.363

 P for trend

  

0.381

 

0.134

 

0.133

 

0.115

  1. Model 1: Adjusted for age, sex, education level, race, smoking status, drinking status, years of hypertension diagnosis, years of diabetes diagnosis, depression, body mass index, systolic blood pressure, diastolic blood pressure, heart rate, and history of CVD
  2. Model 2: Adjusted for model 1 covariables plus plasma total cholesterol, HbA1c, LDL-C, and eGFR
  3. Model 3: Adjusted for model 2 covariables plus statin, insulin, non-dihydropyridine calcium channel blockers, dihydropyridine calcium channel blockers, thiazolidinediones, and thiazide diuretics treatment
  4. The bold values indicate that comparison between groups with significant statistical significance (P value < 0.05)
  5. CI confidence interval, CVD cardiovascular disease, HR hazard ratio, MACEs major adverse cardiac events, MI myocardial infarction, TyG index triglyceride-glucose index
Back to article page

Cardiovascular Diabetology

ISSN: 1475-2840