Adjustment of the GRACE score by the triglyceride glucose index improves the prediction of clinical outcomes in patients with acute coronary syndrome undergoing percutaneous coronary intervention

Table 5 Evaluation the incremental prognostic value of adding the TyG index to the GRACE score to predict clinical outcomes

	C-index (95% CI)	P value	NRI (95% CI)	P value	IDI (95% CI)	P value
MACEs
GRACE score	0.735 (0.682, 0.788)	< 0.01	Ref.	Ref.	Ref.	Ref.
GRACE score + FBG	0.735 (0.681, 0.789)	< 0.01	0.068 (-0.165,0.248))	0.50	0.001 (-0.001,0.013)	0.39
GRACE score + TyG index	0.744 (0.688, 0.800)	< 0.01	0.282 (0.028, 0.426)	0.02	0.019 (0.004, 0.046)	0.01
All-cause death
GRACE score	0.750 (0.690, 0.810)	< 0.01	Ref.	Ref.	Ref.	Ref.
GRACE score + FBG	0.753 (0.694, 0.812)	< 0.01	0.085 (− 0.193, 0.203)	0.41	0.002 (-0.001, 0.025)	0.39
GRACE score + TyG index	0.765 (0.704, 0.826)	< 0.01	0.308 (0.017, 0.445)	0.03	0.026 (0.004, 0.053)	<0.01
Cardiac death
GRACE score	0.776 (0.708, 0.844)	<0.01	Ref.	Ref.	Ref.	Ref.
GRACE score + FBG	0.776 (0.708, 0.844)	< 0.01	0.079 (− 0.145, 0.241)	0.49	0.000 (− 0.001, 0.019)	0.52
GRACE score + TyG index	0.785 (0.714, 0.856)	< 0.01	0.336 (0.031, 0.485)	0.01	0.015 (0.003, 0.047)	<0.01
All-cause death, MI, or unplanned revascularization
GRACE score	0.655 (0.609, 0.701)	< 0.01	Ref.	Ref.	Ref.	Ref.
GRACE score + FBG	0.658 (0.612, 0.704)	< 0.01	0.099 (-0.067,0.231)	0.23	0.002 (0.000, 0.009)	0.20
GRACE score + TyG index	0.673 (0.626, 0.720)	< 0.01	0.267 (0.106, 0.418)	< 0.01	0.017 (0.005, 0.035)	<0.01

MACEs indicates major adverse cardiac events, defined as a composite of all-cause death and nonfatal myocardial infarction. GRACE score, Global Registry of Acute Coronary Events score; TyG index, the triglyceride-glucose index; MI, myocardial infarction; CI, confidence interval; NRI, net reclassification improvement; IDI, integrated discrimination improvement

ISSN: 1475-2840