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Table 2 The hazard ratio (HR) of stroke and its subgroup in hypertensive patients according to trajectories of TyG from 2006 to 2010

From: Triglyceride-glucose index trajectory and stroke incidence in patients with hypertension: a prospective cohort study

 

Low-Stable

Moderate low-stable

Moderate high-stable

Elevated-stable

Elevated-increasing

Stroke

     

 Case/Total

149/2483

715/9666

460/5759

159/1741

36/275

 IR

6.52

7.97

8.62

9.91

14.67

 Model 1

1 (reference)

1.33 (1.11, 1.58)

1.53 (1.27, 1.85)

1.84 (1.47, 2.31)

2.97 (2.06, 4.29)

 Model 2

1 (reference)

1.27 (1.07, 1.53)

1.35 (1.11, 1.64)

1.44 (1.12, 1.84)

2.24 (1.51, 3.32)

 Model 3

1 (reference)

1.26 (1.06, 1.52)

1.35 (1.10, 1.64)

1.43 (1.13, 1.83)

2.21 (1.49, 3.28)

Ischemic stroke

     

 Case/Total

127/2483

628/9666

417/5759

147/1741

32/275

 IR

5.54

6.98

7.79

9.13

12.95

 Model 1

1 (reference)

1.37 (1.13, 1.66)

1.64 (1.34, 2.01)

2.01 (1.58, 2.55)

3.11 (2.10, 4.60)

 Model 2

1 (reference)

1.31 (1.07, 1.58)

1.41 (1.14, 1.74)

1.52 (1.17, 1.97)

2.20 (1.45, 3.34)

 Model 3

1 (reference)

1.30 (1.07, 1.57)

1.40 (1.13, 1.73)

1.51 (1.16, 1.95)

2.16 (1.42, 3.29)

Hemorrhagic stroke

     

 Case/Total

32/2483

106/9666

54/5759

19/1741

4/275

 IR

1.37

1.15

0.98

1.14

1.52

 Model 1

1 (reference)

0.89 (0.60, 1.32)

0.79 (0.51, 1.24)

0.96 (0.54, 1.70)

1.37 (0.48, 3.89)

 Model 2

1 (reference)

0.92 (0.62, 1.39)

0.84 (0.52, 1.36)

0.99 (0.53, 1.86)

1.71 (0.56, 5.19)

 Model 3

1 (reference)

0.94 (0.63, 1.40)

0.86 (0.54, 1.38)

1.02 (0.55, 1.90)

1.77 (0.58, 5.37)

  1. TyG triglyceride-glucose index, IR incidence rate (per 1000 person-years); Model: 1 adjusted for age, sex; Model 2: adjusted for heart rate, BMI, SBP, DBP, total cholesterol, hs-CRP, current smoker, current drinker, physical activity, education level, diabetes mellitus and atrial fibrillation on the basis of model 1; Model 3: included variables in model 2 and further adjusted for hypoglycemic drugs, anti-hypertensive drugs and lipid-lowering drugs