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Table 1 Patient characteristics stratified by ICU/death outcome

From: Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19

 

In-sample

Out-of-sample

No ICU/death

ICU/death

 

No ICU/death

ICU/death

 

(n=122)

(n=221)

P

(n=112)

(n=82)

P

Age (yrs), mean ± SD

62.2 ± 17.5

60.9 ± 16.0

0.47

64.3 ± 18.1

63.8 ± 16.3

0.83

Age (yrs), n (%)

      

 <65

68 (55.7)

132 (59.7)

0.55

53 (47.3)

39 (47.6)

1.0

 ≥65

54 (44.3)

89 (40.3)

 

59 (52.7)

43 (52.4)

 

Gender,n(%)

      

 Male

75 (61.5)

144 (65.2)

0.57

56 (50.0)

52 (63.4)

0.09

 Female

47 (38.5)

77 (34.8)

 

56 (50.0)

30 (36.6)

 

Race/Ethnicity(Self-Reported),n(%)

      

 Hispanic

37 (30.0)

89 (40.3)

0.32

28 (25.0)

25 (30.5)

0.87

 Non-HispanicBlack/AA

9 (7.4)

21 (9.5)

 

15 (13.4)

9 (11.0)

 

 Non-HispanicWhite

54 (44.3)

77 (34.8)

 

56 (50.0)

37 (45.1)

 

 Other

7 (5.7)

11 (5.0)

 

8 (7.1)

6 (7.3)

 

 Unknown/missing

15 (12.3)

23 (10.4)

 

5 (4.5)

5 (6.1)

 

 BMI(kg/m2),mean±SD

29.4±7.0

31.7±7.0

0.006

28±6.8

29.6±7.3

0.14

BMICategory,n(%)

      

 Underweight/normal

29 (25.7)

32 (16.8)

4×10−4

33 (31.1)

17 (24.3)

0.58

 Overweight

45 (39.8)

48 (25.3)

 

38 (35.8)

26 (37.1)

 

 Obese

39 (34.5)

110 (57.9)

 

35 (33.0)

27 (38.6)

 

 CURB-65 Score, mean ± SD

1.0 ± 0.90

1.2 ± 1.0

0.003

1.3 ± 1.1

1.5 ± 1.1

0.20

Comorbidities, n (%)

      

 Type 2 diabetes

41 (33.6)

93 (42.1)

0.15

40 (35.7)

29 (35.4)

1.0

 CAD

22 (18.0)

29 (13.1)

0.29

21 (18.8)

12 (14.6)

0.58

 COPD/asthma

32 (26.2)

38 (17.2)

0.06

27 (24.1)

15 (18.3)

0.43

 Cancer (active)

7 (5.7)

7 (3.2)

0.39

9 (8.0)

4 (4.9)

0.56

 Renal disease

20 (16.4)

44 (19.9)

0.51

29 (25.9)

18 (22.0)

0.64

Hospital Labs, mean ± SD

      

 D-dimer (ng/L)

1006 ± 633

1510 ± 1,113

3×10−5

1,622 ± 1282

1971 ± 1674

0.14

 CRP (mg/L)

72.6 ± 66.8

140 ± 85.9

5×10−12

82.1 ± 68.3

126 ± 80.2

2×10−4

 LDH (U/L)

296 ± 97.9

452 ± 230

3×10−11

298 ± 94

435 ± 184

3×10−9

Troponin (ng/L)

31.8 ± 50.7

33.6 ± 37.9

0.76

42.3 ± 54.0

38.9 ± 40.8

0.69

 Ferritin (µg/L)

526 ± 430

1118 ± 1360

1x10−5

672 ± 681

1502 ± 2052

2×10−4

 Creatine kinase (U/L)

209 ± 335

376 ± 649

0.01

180 ± 238

250 ± 265

0.08

 Absolute lymphocyte count (K/uL)

1.1 ± 0.5

1.0 ± 0.7

0.31

1.1 ± 0.6

0.9 ± 0.4

0.01

  1. Patients who suffered the ICU/death outcome (defined as ICU admission or death within 28 days of presentation to care) were compared with those who did not suffer ICU/death across demographic factors, clinical variables, and hospital laboratory tests using a two-sided t-test for continuous variables and chi-square test for categorical variables. All race/ethnicity categories were self-reported. BMI categorization: < 18.5 kg/m2 for underweight, 18.5–24.9 kg/m2 for normal weight, 25.0–29.9 kg/m2 for overweight, and ≥ 30.0 kg/m2 for obese. SD Standard deviation, AA African American, BMI body mass index, CAD coronary artery disease, COPD chronic obstructive pulmonary disease, CRP C-reactive protein, LDH lactate dehydrogenase