Fig. 1
Association between metabolite level at baseline and cardiovascular events during the follow-up. Shown are the hazard ratio (x-axis) per 1 SD of the metabolite level) of metabolites (rows) associated with any cardiovascular event (upper panel) and cardiovascular mortality (lower panel). Association and 95% confidence intervals are shown from the crude model (left panel) and from the model adjusted for clinical covariates; sex, baseline age, Hemoglobin A1c, mean arterial pressure, smoking, BMI, LDL cholesterol, estimated glomerular filtration rate, urinary albumin excretion rate and previous cardiovascular disease (right panel). Metabolites with a crude association at FDR < 5% are included in the figure, and associations with p < 0.05 are shown in red