Table 3 Association of statin exposure (cumulative supply, cumulative dose) with normalized FG based on FG measurements from all statin users with various FG-influencing drug filters
From: Modest effect of statins on fasting glucose in a longitudinal electronic health record based cohort
Filter | Univariate model | Multivariate model | ||||||
|---|---|---|---|---|---|---|---|---|
Cumulative supply | Cumulative dose | Cumulative supply | Cumulative dose | |||||
Regress coeff (s.e.) | p-value (R2) | Regress coeff (s.e.) | p-value (R2) | Regress coeff (s.e.) | p-value (R2) | Regress coeff (s.e.) | p-value (R2) | |
None n = 157,381 | 0.00373 (0.00041) | 2.47E−19 (0.0005) | 0.00214 (0.00031) | 9.44E−12 (0.0003) | 0.00323 (0.00053) | 1.49E−09 (0.0005) | 0.00060 (0.00041) | 1.41E−01 (0.0005) |
Diabetic n = 137,629 | 0.00523 (0.00041) | 4.20E−37 (0.0012) | 0.00296 (0.00032) | 1.29E−20 (0.0006) | 0.00468 (0.00053) | 1.06E−18 (0.0012) | 0.00067 (0.00041) | 1.04E−01 (0.0012) |
Other n = 121,015 | 0.00392 (0.00046) | 1.42E−17 (0.0006) | 0.00243 (0.00036) | 1.24E−11 (0.0004) | 0.00326 (0.00060) | 4.55E−08 (0.0006) | 0.00081 (0.00047) | 8.39E−02 (0.0006) |
All n = 106,913 | 0.00512 (0.00046) | 5.38E−29 (0.0012) | 0.00324 (0.00037) | 9.66E−19 (0.00070) | 0.00428 (0.00060) | 6.64E−13 (0.0012) | 0.00105 (0.00048) | 2.70E−02 (0.0012) |