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Table 5 Factors and individual a priori variables associated with progression from prediabetes to diabetes

From: Multi-dimensional characterization of prediabetes in the Project Baseline Health Study

PCA factor or individual variable tested

Primary variables in PCA factor

Univariate model

Adjusted model †

OR

(95% CI)

p

>q*

OR (95% CI)

p

Factor 1

Sit/rise score, one-leg balance, 6-minute walk, body mass index (BMI) (−), waist circumference (−)

0.6 (0.5,0.9)

0.002

0.04

0.7 (0.5,0.9) **

0.01

Factor 32

Heart failure, C-reactive protein (CRP)

1.4 (1.1,1.7)

0.002

0.04

1.2 (0.9,1.5)

0.2

  1. OR, odds ratio; CI, confidence interval
  2. OR > 1: higher levels of the factor are associated with higher odds of progression from prediabetes to diabetes; OR < 1: higher levels of the factor are associated with lower odds of progression from prediabetes to diabetes
  3. † Adjusted for age, sex, race, body mass index (BMI), systolic blood pressure, and history of hypertension
  4. *False discovery rate (FDR)-adjusted p-values
  5. ** Factor 1 model is not adjusted for BMI, which is a heavily-loaded component of the factor