Table 3 PCA factors significantly associated with diabetes groups in order of overall significance
From: Multi-dimensional characterization of prediabetes in the Project Baseline Health Study
Factor | Primary variables | Overall association with diabetes groups | Post-hoc pairwise comparisons, p† | ||||
|---|---|---|---|---|---|---|---|
p | q‡ | DM vs. preDM | DM vs. noDM | PreDM vs. noDM | Category* | ||
Factor 9 | HbA1c, diabetes, glucose, selection for high-risk cardiovascular disease (CVD) cohort | < 10− 70 | < 10− 70 | < 10− 70 | < 10− 70 | < 10− 70 | Monotonic |
Factor 1 | Sit/rise score, one-leg balance, 6-minute walk, body mass index (BMI) (−), waist circumference (−) | 2 × 10− 22 | 1 × 10− 21 | 0.02 | < 10− 70 | < 10− 70 | Monotonic |
Factor 12 | Total cholesterol, low-density lipoprotein (LDL) cholesterol | 4 × 10− 11 | 2 × 10− 10 | < 10− 70 | 1 × 10− 5 | 1 × 10− 4 | Misc. |
Factor 8 | Mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), red blood cells (RBC) (−) | 2 × 10− 10 | 8 × 10− 10 | 0.4 | 6 × 10− 4 | 1 × 10− 9 | Concordant |
Factor 2 | Forced vital capacity (FVC), diffusing capacity for carbon monoxide (DLCO), forced expiratory volume (FEV1), hand grip strength, hemoglobin, hematocrit, red blood cells (abs), 6-minute walk, sex | 6 × 10− 7 | 2 × 10− 6 | 1 | 4 × 10− 4 | 2 × 10− 5 | Concordant |
Factor 32 | Heart failure, C-reactive protein (CRP) | 3 × 10− 4 | 6 × 10− 4 | 0.001 | 3 × 10− 4 | 1 | Misc. |
Factor 3 | Smoking, selection for high-risk lung cancer cohort, selection for high-risk CVD cohort, vitamin D (−) | 3 × 10− 4 | 7 × 10− 4 | 0.3 | 7 × 10− 4 | 0.05 | Concordant |
Factor 10 | Left ventricular ejection fraction (LVEF), left ventricular inner dimension end systole (LVIDs) (−) | 7 × 10− 4 | 0.001 | 0.9 | 0.05 | 0.002 | Concordant |
Factor 20 | Basophils | 0.002 | 0.004 | 0.002 | 0.02 | 0.2 | Misc. |
Factor 6 | White blood cells (WBC), lymphocytes, neutrophils, monocytes | 0.004 | 0.006 | 0.5 | 0.008 | 0.1 | Misc. |
Factor 11 | Urine creatinine, specific gravity, urine albumin, pH (−) | 0.01 | 0.02 | 0.1 | 0.008 | 0.7 | Misc. |
Factor 31 | Atrial fibrillation, selection for high-risk breast/ovarian cancer cohort (−) | 0.03 | 0.04 | 0.4 | 0.03 | 0.4 | Misc. |