Fig. 2

AZD5069 does not improve glucose tolerance under high fat diet conditions. A The graph shows the glucose concentration time curve over 2 h following a glucose bolus injection in mice at 16 weeks on each of the treatment arms. B IPGTT AUC in mice in the three diet arms over the 16 week study period was significantly higher in mice in the HF and the HF + AZD diet arms compared to CN diet as indicated (**). The only time point where AUC in mice in the HF and HF + AZD diet arms were significantly different from each other was at the 8 week time point (†). C C-Peptide concentrations were measured during the same IPGTT experiments. D C-Peptide AUC was not significantly different in mice among the three diet arms, although mice on the HF diet exhibited significantly higher C-Peptide AUC than those in the CN diet in the IPGTT at the 16 week time point. The symbols in graphs A–C and the bars in graph D show the median of each of the measurements among n = 8 mice in each of the diet arms and the error bars show the SD. Statistical analysis was performed with repeated measures two-way ANOVA or a one-way ANOVA with Bonferonni post tests as appropriate. Significant differences are shown with an asterisk (*) or a dagger (†) where p < 0.05 and ** where p < 0.01