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Table 1 Univariate association (HR [95% CI]) of individual baseline liver markers with CV and renal outcomes

From: Liver function markers predict cardiovascular and renal outcomes in the CANVAS Program

  HF (n = 243) CV death (n = 453) HF or CV death (n = 652) All deaths (n = 681) MACE (n = 1011) Renal endp.a (n = 847)
Top quartile
 ALT 0.73 [0.52–0.99] 0.59 [0.45–0.75] 0.63 [0.51–0.77] 0.64 [0.52–0.78] 0.84 [0.72–0.98] 0.75 [0.64–0.89]
 AST 1.04 [0.76–1.39] 0.80 [0.63–1.01] 0.89 [0.73–1.07] 0.89 [0.74–1.07] 0.99 [0.85–1.14] 0.94 [0.80–1.10]
 ALP 1.51 [1.15–1.98] 1.48 [1.20–1.81] 1.46 [1.23–1.72] 1.44 [1.21–1.69] 1.28 [1.11–1.47] 1.28 [1.10–1.48]
 γGT 1.85 [1.42–2.40] 1.03 [0.83–1.28] 1.29 [1.09–1.53] 1.18 [0.94–1.33] 1.10 [0.95–1.26] 1.06 [0.90–1.23]
 Bilirubin 1.23 [0.93–1.63] 0.82 [0.64–1.02] 0.95 [0.78–1.13] 0.85 [0.70–1.02] 1.00 [0.86–1.15] 0.94 [0.80–1.10]
Log [baseline]
 ALT [U/L] 0.62 [0.46–0.82] 0.52 [0.42–0.64] 0.55 [0.46–0.66] 0.55 [0.46–0.65] 0.84 [0.73–0.96] 0.72 [0.62–0.84]
 AST [U/L] 1.03 [0.71–1.47] 0.64 [0.48–0.85] 0.75 [0.59–0.94] 0.74 [0.59–0.93] 0.91 [0.76–1.09] 0.80 [0.66–0.98]
 ALP [U/L] 1.88 [1.24–2.83] 1.75 [1.29–2.38] 1.68 [1.30–2.17] 1.54 [1.20–1.98] 1.43 [1.16–1.75] 1.51 [1.21–1.89]
 γGT [U/L] 1.65 [1.39–1.95] 1.14 [0.99–1.31] 1.30 [1.17–1.46] 1.13 [1.09–1.27] 1.17 [1.06–1.28] 1.08 [0.98–1.20]
 Bilirubin [µM] 1.07 [0.81–1.41] 0.87 [0.71–1.08] 0.94 [0.79–1.12] 0.85 [0.72–1.01] 1.02 [0.88–1.17] 0.85 [0.73–0.98]
  1. Table entries are hazard ratio (HR) and 95% confidence interval. Statistically significant estimates are in bold
  2. ALT alanine aminotransferase; AST aspartic aminotransferase; γGT gamma-glutamyl transferase; ALP alkaline phosphatase; CV cardiovascular; HF hospitalized heart failure; MACE major adverse cardiovascular events
  3. aRenal endp. = composite of a > 40% decline in estimated glomerular filtration rate, renal replacement, renal death, and progression to macroalbuminuria