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Table 2 Sensitivity analysis by excluding the ODYSSEY LONG TERM trial

From: PCSK9 inhibitors for secondary prevention in patients with cardiovascular diseases: a bayesian network meta-analysis

Intervention

All-cause mortality

Serious adverse events

RR (95% CrI)

RR (95% CrI)

Compared with placebo

 Alirocumab

0.84 [0.73, 0.97]

0.94 [0.90, 0.99]

 Evolocumab

1.04 [0.91, 1.18]

1.00 [0.96, 1.04]

 Inclisiran

1.00 [0.58, 1.72]

0.92 [0.81, 1.04]

Compared with alirocumab

 Evolocumab

1.24 [1.02, 1.50]

1.06 [1.00, 1.13]

 Inclisiran

1.18 [0.67, 2.08]

0.98 [0.85, 1.12]

Compared with evolocumab

 Inclisiran

0.96 [0.55, 1.68]

0.92 [0.80, 1.05]

  1. RR relative risk, CrI credibility interval