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Table 1 Baseline characteristics of study participants according to the TyG variability tertiles

From: Triglyceride-glucose index variability and incident cardiovascular disease: a prospective cohort study

 

Total (n = 49,579)

TyG index variability

P value

SMD

Tertile 1 (n = 16,527)

Tertile 2 (n = 16,526)

Tertile 3 (n = 16,526)

Age, years

52.5 ± 11.8

53.3 ± 12.1

52.7 ± 11.8

51.6 ± 11.5

 < 0.001

0.11

Age ≥ 60 years

12,093 (24.4)

4451 (26.9)

4135 (25.0)

3507 (21.2)

 < 0.001

0.11

Male sex

37,977 (76.6)

12,413 (75.1)

12,579 (76.1)

12,985 (78.6)

 < 0.001

0.07

Education (≥ high school)

13,766 (27.9)

4633 (28.1)

4671 (28.4)

4462 (27.1)

0.028

0.03

Income (≤ 1000 RMB/month)

22,510 (46.5)

7323 (45.3)

7521 (46.6)

7666 (47.7)

 < 0.001

0.03

Current smoker

16,901 (34.2)

5397 (32.8)

5552 (33.7)

5952 (36.2)

 < 0.001

0.06

Alcohol drinker

17,589 (35.6)

5626 (34.2)

5704 (34.6)

6259 (38.0)

 < 0.001

0.08

Physical activity

6857 (13.9)

2448 (14.9)

2251 (13.7)

2158 (13.1)

 < 0.001

0.03

Hypertension

22,298 (45.0)

7403 (44.8)

7333 (44.4)

7562 (45.8)

0.030

0.02

Diabetes

3154 (6.4)

919 (5.6)

932 (5.6)

1303 (7.9)

 < 0.001

0.09

Hypercholesterolaemia

19,289 (38.9)

6435 (38.9)

6326 (38.3)

6528 (39.5)

0.074

0.02

Chronic kidney disease

3040 (6.1)

1075 (6.5)

1027 (6.2)

938 (5.7)

0.006

0.03

Antihypertensive agents

4548 (9.3)

1591 (9.7)

1509 (9.2)

1448 (8.9)

0.026

0.02

Body mass index, kg/m2

25.0 ± 3.4

25.0 ± 3.4

25.0 ± 3.4

25.1 ± 3.3

0.001

0.04

Body mass index ≥ 25 kg/m2

24,984 (50.4)

8276 (50.1)

8246 (49.9)

8462 (51.2)

0.036

0.02

Systolic blood pressure, mm Hg

130.1 ± 19.0

130.1 ± 19.3

129.9 ± 18.9

130.3 ± 18.7

0.113

0.02

Diastolic blood pressure, mm Hg

84.2 ± 10.8

83.9 ± 10.8

84.0 ± 10.8

84.6 ± 10.7

 < 0.001

0.06

Fasting glucose, mmol/L

5.5 ± 1.5

5.4 ± 1.2

5.4 ± 1.1

5.6 ± 2.0

 < 0.001

0.09

Estimated glomerular filtration rate

90.7 ± 19.9

90.0 ± 19.7

90.8 ± 20.2

91.2 ± 19.9

 < 0.001

0.04

Total cholesterol, mmol/L

5.0 ± 1.3

5.0 ± 1.2

5.0 ± 1.1

5.0 ± 1.4

0.108

0.02

LDL-C, mmol/L

2.6 ± 0.9

2.6 ± 0.9

2.6 ± 0.8

2.6 ± 1.2

0.021

0.02

HDL-C, mmol/L

1.6 ± 0.5

1.6 ± 0.5

1.6 ± 0.6

1.5 ± 0.5

 < 0.001

0.07

Triglycerides, mmol/L

1.3 (0.9, 1.9)

1.2 (0.9, 1.8)

1.2 (0.9, 1.8)

1.4 (0.9, 2.2)

 < 0.001

0.21

Hs-CRP, mg/dL

1.0 (0.5, 2.4)

1.0 (0.5, 2.4)

1.0 (0.5, 2.4)

1.0 (0.5, 2.5)

0.391

0.01

Hs-CRP > 3 mg/dL

9662 (19.7)

3216 (19.7)

3162 (19.3)

3284 (20.2)

0.143

0.02

Baseline TyG index

8.7 ± 0.7

8.6 ± 0.6

8.6 ± 0.6

8.8 ± 0.7

 < 0.001

0.22

Mean TyG index

8.6 ± 0.6

8.6 ± 0.5

8.6 ± 0.5

8.7 ± 0.6

 < 0.001

0.27

Variability of TyG index

0.2 (0.1, 0.4)

0.1 (0.0, 0.1)

0.2 (0.2, 0.3)

0.5 (0.4, 0.7)

 < 0.001

2.24

  1. Values are presented as number (%), mean ± SD, or median (interquartile range)
  2. TyG index triglyceride-glucose index, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, Hs-CRP high-sensitivity C-reactive protein, SMD standardized mean difference