| Total (n = 49,579) | TyG index variability | P value | SMD | ||
---|---|---|---|---|---|---|
Tertile 1 (n = 16,527) | Tertile 2 (n = 16,526) | Tertile 3 (n = 16,526) | ||||
Age, years | 52.5 ± 11.8 | 53.3 ± 12.1 | 52.7 ± 11.8 | 51.6 ± 11.5 |  < 0.001 | 0.11 |
Age ≥ 60 years | 12,093 (24.4) | 4451 (26.9) | 4135 (25.0) | 3507 (21.2) |  < 0.001 | 0.11 |
Male sex | 37,977 (76.6) | 12,413 (75.1) | 12,579 (76.1) | 12,985 (78.6) |  < 0.001 | 0.07 |
Education (≥ high school) | 13,766 (27.9) | 4633 (28.1) | 4671 (28.4) | 4462 (27.1) | 0.028 | 0.03 |
Income (≤ 1000 RMB/month) | 22,510 (46.5) | 7323 (45.3) | 7521 (46.6) | 7666 (47.7) |  < 0.001 | 0.03 |
Current smoker | 16,901 (34.2) | 5397 (32.8) | 5552 (33.7) | 5952 (36.2) |  < 0.001 | 0.06 |
Alcohol drinker | 17,589 (35.6) | 5626 (34.2) | 5704 (34.6) | 6259 (38.0) |  < 0.001 | 0.08 |
Physical activity | 6857 (13.9) | 2448 (14.9) | 2251 (13.7) | 2158 (13.1) |  < 0.001 | 0.03 |
Hypertension | 22,298 (45.0) | 7403 (44.8) | 7333 (44.4) | 7562 (45.8) | 0.030 | 0.02 |
Diabetes | 3154 (6.4) | 919 (5.6) | 932 (5.6) | 1303 (7.9) |  < 0.001 | 0.09 |
Hypercholesterolaemia | 19,289 (38.9) | 6435 (38.9) | 6326 (38.3) | 6528 (39.5) | 0.074 | 0.02 |
Chronic kidney disease | 3040 (6.1) | 1075 (6.5) | 1027 (6.2) | 938 (5.7) | 0.006 | 0.03 |
Antihypertensive agents | 4548 (9.3) | 1591 (9.7) | 1509 (9.2) | 1448 (8.9) | 0.026 | 0.02 |
Body mass index, kg/m2 | 25.0 ± 3.4 | 25.0 ± 3.4 | 25.0 ± 3.4 | 25.1 ± 3.3 | 0.001 | 0.04 |
Body mass index ≥ 25 kg/m2 | 24,984 (50.4) | 8276 (50.1) | 8246 (49.9) | 8462 (51.2) | 0.036 | 0.02 |
Systolic blood pressure, mm Hg | 130.1 ± 19.0 | 130.1 ± 19.3 | 129.9 ± 18.9 | 130.3 ± 18.7 | 0.113 | 0.02 |
Diastolic blood pressure, mm Hg | 84.2 ± 10.8 | 83.9 ± 10.8 | 84.0 ± 10.8 | 84.6 ± 10.7 |  < 0.001 | 0.06 |
Fasting glucose, mmol/L | 5.5 ± 1.5 | 5.4 ± 1.2 | 5.4 ± 1.1 | 5.6 ± 2.0 |  < 0.001 | 0.09 |
Estimated glomerular filtration rate | 90.7 ± 19.9 | 90.0 ± 19.7 | 90.8 ± 20.2 | 91.2 ± 19.9 |  < 0.001 | 0.04 |
Total cholesterol, mmol/L | 5.0 ± 1.3 | 5.0 ± 1.2 | 5.0 ± 1.1 | 5.0 ± 1.4 | 0.108 | 0.02 |
LDL-C, mmol/L | 2.6 ± 0.9 | 2.6 ± 0.9 | 2.6 ± 0.8 | 2.6 ± 1.2 | 0.021 | 0.02 |
HDL-C, mmol/L | 1.6 ± 0.5 | 1.6 ± 0.5 | 1.6 ± 0.6 | 1.5 ± 0.5 |  < 0.001 | 0.07 |
Triglycerides, mmol/L | 1.3 (0.9, 1.9) | 1.2 (0.9, 1.8) | 1.2 (0.9, 1.8) | 1.4 (0.9, 2.2) |  < 0.001 | 0.21 |
Hs-CRP, mg/dL | 1.0 (0.5, 2.4) | 1.0 (0.5, 2.4) | 1.0 (0.5, 2.4) | 1.0 (0.5, 2.5) | 0.391 | 0.01 |
Hs-CRP > 3 mg/dL | 9662 (19.7) | 3216 (19.7) | 3162 (19.3) | 3284 (20.2) | 0.143 | 0.02 |
Baseline TyG index | 8.7 ± 0.7 | 8.6 ± 0.6 | 8.6 ± 0.6 | 8.8 ± 0.7 |  < 0.001 | 0.22 |
Mean TyG index | 8.6 ± 0.6 | 8.6 ± 0.5 | 8.6 ± 0.5 | 8.7 ± 0.6 |  < 0.001 | 0.27 |
Variability of TyG index | 0.2 (0.1, 0.4) | 0.1 (0.0, 0.1) | 0.2 (0.2, 0.3) | 0.5 (0.4, 0.7) |  < 0.001 | 2.24 |