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Table 2 Independent effects of insulin resistance and hemoglobin A1c on left ventricular parameters assessed by multivariate MR

From: Effects of glycemic traits on left ventricular structure and function: a mendelian randomization study

 

IVW

Weighted-median

MR-Egger

β (95% CI)

P-value

β (95% CI)

P-value

β (95% CI)

P-value

LV end-diastolic volume, ml

 IR

− 0.27 (− 0.47, − 0.08)

0.006

− 0.25 (− 0.48, − 0.01)

0.038

− 0.32 (− 0.61, − 0.03)

0.030

 HbA1c

− 0.06 (− 0.34, 0.21)

0.647

0.01 (− 0.34, 0.36)

0.943

− 0.07 (− 0.34, 0.21)

0.643

LV end-systolic volume, ml

 IR

− 0.31 (− 0.51, − 0.11)

0.002

− 0.28 (− 0.52, − 0.03)

0.027

− 0.38 (− 0.67, − 0.08)

0.012

 HbA1c

0.11 (− 0.17, 0.39)

0.437

0.16 (− 0.20, 0.51)

0.392

0.11 (− 0.17, 0.39)

0.445

LV ejection fraction, %

 IR

0.19 (0.03, 0.35)

0.022

0.06 (− 0.17, 0.29)

0.619

0.27 (0.03, 0.51)

0.026

 HbA1c

− 0.23 (− 0.46, 0.003)

0.053

− 0.26 (− 0.59, 0.06)

0.113

− 0.23 (− 0.46, 0.01)

0.055

LV mass, g

 IR

0.15 (− 0.03, 0.33)

0.093

0.01 (− 0.25, 0.27)

0.935

− 0.04 (− 0.30, 0.22)

0.748

 HbA1c

0.03 (− 0.23, 0.28)

0.827

0.02 (− 0.30, 0.34)

0.915

0.02 (− 0.22, 0.27)

0.851

LV mass to end-diastolic volume ratio, g/ml

 IR

0.48 (0.30, 0.65)

7.98 × 10−8

0.62 (0.35, 0.89)

5.79 × 10−6

0.29 (0.03, 0.54)

0.024

 HbA1c

0.15 (− 0.09, 0.40)

0.223

0.08 (− 0.25, 0.41)

0.634

0.15 (− 0.09, 0.39)

0.226

  1. IR insulin resistance, HbA1c hemoglobin A1c, LV left ventricular, IVW inverse-variance weighted, CI confidence interval, MR Mendelian randomization. In multivariate MR analysis of LV parameters, rs8101064 and rs6474359 cannot be extracted from the summary data of LV parameters and rs2943645 cannot be extracted from the summary data of HbA1c. In addition, rs10774625 was removed because it was associated with LV end-diastolic volume at genome-wide significance level. After LD clumping at a threshold of r2 < 0.001 (clumping window: 10,000 kB), 71 independent SNPs were used in the analysis