Fig. 2
MR estimates of insulin resistance on left ventricular parameters. Estimates are derived from IVW MR analyses. 53-SNPs instruments were identified by Lotta et al., but rs8101064 cannot be extracted in the outcome dataset, so 52-SNPs instruments were used in the main analysis. 51-SNPs instruments with the exclusion of rs1011685 (near LPL gene). 46-SNPs instruments after linkage disequilibrium (LD) clumping at a threshold of r2 < 0.001 (clumping window: 10,000 kB). 43-SNPs instruments after exclusion of 9 SNPs individually associated with BMI at P < 0.001 using GIANT summary statistics. 28-SNPs instruments after exclusion of 25 SNPs (rs8101064 is one of these 25 SNPs) previously associated with triglycerides or high-density lipoprotein cholesterol at genome-wide significance. 20-SNPs instruments after exclusion of 32 SNPs previously associated with potential confounders at genome-wide significance. SNP single nucleotide polymorphism, LV left ventricular